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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, Siegel D, Perron M, Bannister R, Hui HC, Larson N, Strickley R, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Shurtleff AC, Retterer CJ, Gharaibeh D, Zamani R, Kenny T, Eaton BP, Grimes E, Welch LS, Gomba L, Wilhelmsen CL, Nichols DK, Nuss JE, Nagle ER, Kugelman JR, Palacios G, Doerffler E, Neville S, Carra E, Clarke MO, Zhang L, Lew W, Ross B, Wang Q, Chun K, Wolfe L, Babusis D, Park Y, Stray KM, Trancheva I, Feng JY, Barauskas O, Xu Y, Wong P, Braun MR, Flint M, McMullan LK, Chen SS, Fearns R, Swaminathan S, Mayers DL, Spiropoulou CF, Lee WA, Nichol ST, Cihlar T, Bavari S. Warren TK, et al. Among authors: donnelly g. Nature. 2016 Mar 17;531(7594):381-5. doi: 10.1038/nature17180. Epub 2016 Mar 2. Nature. 2016. PMID: 26934220 Free PMC article.
Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics.
Warren T, Zumbrun E, Weidner JM, Gomba L, Rossi F, Bannister R, Tarrant J, Reed M, Lee E, Raymond JL, Wells J, Shamblin J, Wetzel K, Donnelly G, Van Tongeren S, Lackemeyer N, Steffens J, Kimmel A, Garvey C, Bloomfield H, Blair C, Singh B, Bavari S, Cihlar T, Porter D. Warren T, et al. Among authors: donnelly g. Viruses. 2020 Jan 13;12(1):92. doi: 10.3390/v12010092. Viruses. 2020. PMID: 31941095 Free PMC article.
Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus.
Porter DP, Weidner JM, Gomba L, Bannister R, Blair C, Jordan R, Wells J, Wetzel K, Garza N, Van Tongeren S, Donnelly G, Steffens J, Moreau A, Bearss J, Lee E, Bavari S, Cihlar T, Warren TK. Porter DP, et al. Among authors: donnelly g. J Infect Dis. 2020 Nov 9;222(11):1894-1901. doi: 10.1093/infdis/jiaa290. J Infect Dis. 2020. PMID: 32479636
Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus.
Warren TK, Kane CD, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Steffens J, Gomba L, Weidner JM, Norris S, Zeng X, Bannister R, Cihlar T, Bavari S, Porter DP, Iversen PL. Warren TK, et al. Among authors: donnelly g. Sci Rep. 2021 Sep 30;11(1):19458. doi: 10.1038/s41598-021-98971-0. Sci Rep. 2021. PMID: 34593911 Free PMC article.
Intensive Care Unit-Like Care of Nonhuman Primates with Ebola Virus Disease.
Blair PW, Kortepeter MG, Downey LG, Madar CS, Downs IL, Martins KA, Rossi F, Williams JA, Madar A, Schellhase CW, Bearss JJ, Zeng X, Bavari S, Soloveva V, Wells JB, Stuthman KS, Garza NL, Vantongeren SA, Donnelly GC, Steffens J, Kalapaca J, Wiseman P, Henry J, Marko S, Chappell M, Lugo-Roman L, Ramos-Rivera E, Hofer C, Blue E, Moore J, Fiallos J, Wetzel D, Pratt WD, Unangst T, Miller A, Sola JJ, Reisler RB, Cardile AP. Blair PW, et al. Among authors: donnelly gc. J Infect Dis. 2021 Aug 16;224(4):632-642. doi: 10.1093/infdis/jiaa781. J Infect Dis. 2021. PMID: 33367826 Free PMC article.
Intracellular conversion and in vivo dose response of favipiravir (T-705) in rodents infected with Ebola virus.
Bixler SL, Bocan TM, Wells J, Wetzel KS, Van Tongeren SA, Garza NL, Donnelly G, Cazares LH, Soloveva V, Welch L, Epstein C, Liang LF, Giesing D, Lenk R, Bavari S, Warren TK. Bixler SL, et al. Among authors: donnelly g. Antiviral Res. 2018 Mar;151:50-54. doi: 10.1016/j.antiviral.2017.12.020. Epub 2017 Dec 28. Antiviral Res. 2018. PMID: 29289664 Free article.
Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus.
Bixler SL, Bocan TM, Wells J, Wetzel KS, Van Tongeren SA, Dong L, Garza NL, Donnelly G, Cazares LH, Nuss J, Soloveva V, Koistinen KA, Welch L, Epstein C, Liang LF, Giesing D, Lenk R, Bavari S, Warren TK. Bixler SL, et al. Among authors: donnelly g. Antiviral Res. 2018 Mar;151:97-104. doi: 10.1016/j.antiviral.2017.12.021. Epub 2017 Dec 28. Antiviral Res. 2018. PMID: 29289666 Free article.
Cholesterol-conjugated stapled peptides inhibit Ebola and Marburg viruses in vitro and in vivo.
Pessi A, Bixler SL, Soloveva V, Radoshitzky S, Retterer C, Kenny T, Zamani R, Gomba G, Gharabeih D, Wells J, Wetzel KS, Warren TK, Donnelly G, Van Tongeren SA, Steffens J, Duplantier AJ, Kane CD, Vicat P, Couturier V, Kester KE, Shiver J, Carter K, Bavari S. Pessi A, et al. Among authors: donnelly g. Antiviral Res. 2019 Nov;171:104592. doi: 10.1016/j.antiviral.2019.104592. Epub 2019 Aug 29. Antiviral Res. 2019. PMID: 31473342 Free article.
308 results