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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
Rappazzo CG, Tse LV, Kaku CI, Wrapp D, Sakharkar M, Huang D, Deveau LM, Yockachonis TJ, Herbert AS, Battles MB, O'Brien CM, Brown ME, Geoghegan JC, Belk J, Peng L, Yang L, Hou Y, Scobey TD, Burton DR, Nemazee D, Dye JM, Voss JE, Gunn BM, McLellan JS, Baric RS, Gralinski LE, Walker LM. Rappazzo CG, et al. Among authors: dye jm. Science. 2021 Feb 19;371(6531):823-829. doi: 10.1126/science.abf4830. Epub 2021 Jan 25. Science. 2021. PMID: 33495307 Free PMC article.
Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR. Jae LT, et al. Among authors: dye jm. Science. 2014 Jun 27;344(6191):1506-10. doi: 10.1126/science.1252480. Science. 2014. PMID: 24970085 Free PMC article.
Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.
Keck ZY, Enterlein SG, Howell KA, Vu H, Shulenin S, Warfield KL, Froude JW, Araghi N, Douglas R, Biggins J, Lear-Rooney CM, Wirchnianski AS, Lau P, Wang Y, Herbert AS, Dye JM, Glass PJ, Holtsberg FW, Foung SK, Aman MJ. Keck ZY, et al. Among authors: dye jm. J Virol. 2015 Oct 14;90(1):279-91. doi: 10.1128/JVI.02172-15. Print 2016 Jan 1. J Virol. 2015. PMID: 26468532 Free PMC article.
Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses.
Holtsberg FW, Shulenin S, Vu H, Howell KA, Patel SJ, Gunn B, Karim M, Lai JR, Frei JC, Nyakatura EK, Zeitlin L, Douglas R, Fusco ML, Froude JW, Saphire EO, Herbert AS, Wirchnianski AS, Lear-Rooney CM, Alter G, Dye JM, Glass PJ, Warfield KL, Aman MJ. Holtsberg FW, et al. Among authors: dye jm. J Virol. 2015 Oct 14;90(1):266-78. doi: 10.1128/JVI.02171-15. Print 2016 Jan 1. J Virol. 2015. PMID: 26468533 Free PMC article.
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site.
Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, Kroeker A, Vu H, Herbert AS, Fusco ML, Nyakatura EK, Lai JR, Keck ZY, Foung SKH, Saphire EO, Zeitlin L, Ward AB, Chandran K, Doranz BJ, Kobinger GP, Dye JM, Aman MJ. Howell KA, et al. Among authors: dye jm. Cell Rep. 2016 May 17;15(7):1514-1526. doi: 10.1016/j.celrep.2016.04.026. Epub 2016 May 5. Cell Rep. 2016. PMID: 27160900 Free PMC article.
Cysteine Cathepsin Inhibitors as Anti-Ebola Agents.
van der Linden WA, Schulze CJ, Herbert AS, Krause TB, Wirchnianski AA, Dye JM, Chandran K, Bogyo M. van der Linden WA, et al. Among authors: dye jm. ACS Infect Dis. 2016 Mar 11;2(3):173-179. doi: 10.1021/acsinfecdis.5b00130. Epub 2016 Jan 20. ACS Infect Dis. 2016. PMID: 27347558 Free PMC article.
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE Jr, Aman MJ, Dye JM, Lai JR, Chandran K. Wec AZ, et al. Among authors: dye jm. Science. 2016 Oct 21;354(6310):350-354. doi: 10.1126/science.aag3267. Epub 2016 Sep 8. Science. 2016. PMID: 27608667 Free PMC article.
157 results