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Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.
Mol Pharmacol. 2006 Jun;69(6):1871-8. doi: 10.1124/mol.105.021832. Epub 2006 Mar 15.
Mol Pharmacol. 2006.
PMID: 16540597
The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.
Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP.
Martey CA, et al.
Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L391-9. doi: 10.1152/ajplung.00062.2005. Epub 2005 Apr 29.
Am J Physiol Lung Cell Mol Physiol. 2005.
PMID: 15863442
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