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Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity.
Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL. Epstein JE, et al. Among authors: edelman r. Science. 2011 Oct 28;334(6055):475-80. doi: 10.1126/science.1211548. Epub 2011 Sep 8. Science. 2011. PMID: 21903775 Clinical Trial.
Successful human infection with P. falciparum using three aseptic Anopheles stephensi mosquitoes: a new model for controlled human malaria infection.
Laurens MB, Billingsley P, Richman A, Eappen AG, Adams M, Li T, Chakravarty S, Gunasekera A, Jacob CG, Sim BK, Edelman R, Plowe CV, Hoffman SL, Lyke KE. Laurens MB, et al. Among authors: edelman r. PLoS One. 2013 Jul 16;8(7):e68969. doi: 10.1371/journal.pone.0068969. Print 2013. PLoS One. 2013. PMID: 23874828 Free PMC article. Clinical Trial.
Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria.
Hoffman SL, Billingsley PF, James E, Richman A, Loyevsky M, Li T, Chakravarty S, Gunasekera A, Chattopadhyay R, Li M, Stafford R, Ahumada A, Epstein JE, Sedegah M, Reyes S, Richie TL, Lyke KE, Edelman R, Laurens MB, Plowe CV, Sim BK. Hoffman SL, et al. Among authors: edelman r. Hum Vaccin. 2010 Jan;6(1):97-106. doi: 10.4161/hv.6.1.10396. Epub 2010 Jan 21. Hum Vaccin. 2010. PMID: 19946222 Review.
Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant.
Hoffman SL, Edelman R, Bryan JP, Schneider I, Davis J, Sedegah M, Gordon D, Church P, Gross M, Silverman C, et al. Hoffman SL, et al. Among authors: edelman r. Am J Trop Med Hyg. 1994 Nov;51(5):603-12. doi: 10.4269/ajtmh.1994.51.603. Am J Trop Med Hyg. 1994. PMID: 7985753 Clinical Trial.
Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection.
Lyke KE, Laurens MB, Strauss K, Adams M, Billingsley PF, James E, Manoj A, Chakravarty S, Plowe CV, Li ML, Ruben A, Edelman R, Green M, Dube TJ, Sim BKL, Hoffman SL. Lyke KE, et al. Among authors: edelman r. Am J Trop Med Hyg. 2015 Dec;93(6):1274-1284. doi: 10.4269/ajtmh.15-0341. Epub 2015 Sep 28. Am J Trop Med Hyg. 2015. PMID: 26416102 Free PMC article. Clinical Trial.
The Controlled Human Malaria Infection Experience at the University of Maryland.
Friedman-Klabanoff DJ, Laurens MB, Berry AA, Travassos MA, Adams M, Strauss KA, Shrestha B, Levine MM, Edelman R, Lyke KE. Friedman-Klabanoff DJ, et al. Among authors: edelman r. Am J Trop Med Hyg. 2019 Mar;100(3):556-565. doi: 10.4269/ajtmh.18-0476. Am J Trop Med Hyg. 2019. PMID: 30675854 Free PMC article.
631 results