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Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α1-antitrypsin-derived peptide motif.
Cruz MA, Bohinc D, Andraska EA, Alvikas J, Raghunathan S, Masters NA, van Kleef ND, Bane KL, Hart K, Medrow K, Sun M, Liu H, Haldeman S, Banerjee A, Lessieur EM, Hageman K, Gandhi A, de la Fuente M, Nieman MT, Kern TS, Maas C, de Maat S, Neeves KB, Neal MD, Sen Gupta A, Stavrou EX. Cruz MA, et al. Nat Nanotechnol. 2022 Sep;17(9):1004-1014. doi: 10.1038/s41565-022-01161-w. Epub 2022 Jul 18. Nat Nanotechnol. 2022. PMID: 35851383 Free PMC article.
Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding.
Sekhon UDS, Swingle K, Girish A, Luc N, de la Fuente M, Alvikas J, Haldeman S, Hassoune A, Shah K, Kim Y, Eppell S, Capadona J, Shoffstall A, Neal MD, Li W, Nieman M, Sen Gupta A. Sekhon UDS, et al. Sci Transl Med. 2022 Jan 26;14(629):eabb8975. doi: 10.1126/scitranslmed.abb8975. Epub 2022 Jan 26. Sci Transl Med. 2022. PMID: 35080915 Free PMC article.