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Systems vaccinology of the BNT162b2 mRNA vaccine in humans.
Arunachalam PS, Scott MKD, Hagan T, Li C, Feng Y, Wimmers F, Grigoryan L, Trisal M, Edara VV, Lai L, Chang SE, Feng A, Dhingra S, Shah M, Lee AS, Chinthrajah S, Sindher SB, Mallajosyula V, Gao F, Sigal N, Kowli S, Gupta S, Pellegrini K, Tharp G, Maysel-Auslender S, Hamilton S, Aoued H, Hrusovsky K, Roskey M, Bosinger SE, Maecker HT, Boyd SD, Davis MM, Utz PJ, Suthar MS, Khatri P, Nadeau KC, Pulendran B. Arunachalam PS, et al. Among authors: feng y, feng a. Nature. 2021 Aug;596(7872):410-416. doi: 10.1038/s41586-021-03791-x. Epub 2021 Jul 12. Nature. 2021. PMID: 34252919 Free PMC article.
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans.
Arunachalam PS, Wimmers F, Mok CKP, Perera RAPM, Scott M, Hagan T, Sigal N, Feng Y, Bristow L, Tak-Yin Tsang O, Wagh D, Coller J, Pellegrini KL, Kazmin D, Alaaeddine G, Leung WS, Chan JMC, Chik TSH, Choi CYC, Huerta C, Paine McCullough M, Lv H, Anderson E, Edupuganti S, Upadhyay AA, Bosinger SE, Maecker HT, Khatri P, Rouphael N, Peiris M, Pulendran B. Arunachalam PS, et al. Among authors: feng y. Science. 2020 Sep 4;369(6508):1210-1220. doi: 10.1126/science.abc6261. Epub 2020 Aug 11. Science. 2020. PMID: 32788292 Free PMC article.
Systems biological assessment of human immunity to BNT162b2 mRNA vaccination.
Arunachalam PS, Scott MKD, Hagan T, Li C, Feng Y, Wimmers F, Grigoryan L, Trisal M, Edara VV, Lai L, Chang SE, Feng A, Dhingra S, Shah M, Lee AS, Chinthrajah S, Sindher T, Mallajosyula V, Gao F, Sigal N, Kowli S, Gupta S, Pellegrini K, Tharp G, Maysel-Auslender S, Bosinger S, Maecker HT, Boyd SD, Davis MM, Utz PJ, Suthar MS, Khatri P, Nadeau KC, Pulendran B. Arunachalam PS, et al. Among authors: feng y, feng a. Res Sq [Preprint]. 2021 Apr 22:rs.3.rs-438662. doi: 10.21203/rs.3.rs-438662/v1. Res Sq. 2021. PMID: 34013244 Free PMC article. Updated. Preprint.
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine.
Li C, Lee A, Grigoryan L, Arunachalam PS, Scott MKD, Trisal M, Wimmers F, Sanyal M, Weidenbacher PA, Feng Y, Adamska JZ, Valore E, Wang Y, Verma R, Reis N, Dunham D, O'Hara R, Park H, Luo W, Gitlin AD, Kim P, Khatri P, Nadeau KC, Pulendran B. Li C, et al. Among authors: feng y. Nat Immunol. 2022 Apr;23(4):543-555. doi: 10.1038/s41590-022-01163-9. Epub 2022 Mar 14. Nat Immunol. 2022. PMID: 35288714 Free PMC article.
Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice.
Grigoryan L, Lee A, Walls AC, Lai L, Franco B, Arunachalam PS, Feng Y, Luo W, Vanderheiden A, Floyd K, Wrenn S, Pettie D, Miranda MC, Kepl E, Ravichandran R, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, Coffman RL, Novack D, Kleanthous H, O'Hagan DT, van der Most R, McLellan JS, Suthar M, Veesler D, King NP, Pulendran B. Grigoryan L, et al. Among authors: feng y. NPJ Vaccines. 2022 May 23;7(1):55. doi: 10.1038/s41541-022-00472-2. NPJ Vaccines. 2022. PMID: 35606518 Free PMC article.
Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine.
Arunachalam PS, Feng Y, Ashraf U, Hu M, Walls AC, Edara VV, Zarnitsyna VI, Aye PP, Golden N, Miranda MC, Green KWM, Threeton BM, Maness NJ, Beddingfield BJ, Bohm RP, Scheuermann SE, Goff K, Dufour J, Russell-Lodrigue K, Kepl E, Fiala B, Wrenn S, Ravichandran R, Ellis D, Carter L, Rogers K, Shirreff LM, Ferrell DE, Deb Adhikary NR, Fontenot J, Hammond HL, Frieman M, Grifoni A, Sette A, O'Hagan DT, Van Der Most R, Rappuoli R, Villinger F, Kleanthous H, Rappaport J, Suthar MS, Veesler D, Wang TT, King NP, Pulendran B. Arunachalam PS, et al. Among authors: feng y. Sci Transl Med. 2022 Aug 17;14(658):eabq4130. doi: 10.1126/scitranslmed.abq4130. Epub 2022 Aug 17. Sci Transl Med. 2022. PMID: 35976993 Free PMC article.
Durability of immune responses to the booster mRNA vaccination against COVID-19.
Arunachalam PS, Lai L, Samaha H, Feng Y, Hu M, Hui HS, Wali B, Ellis M, Huerta C, Bechnack K, Bechnack S, Lee M, Litvack M, Losada C, Grifoni A, Sette A, Zarnitsyna VI, Rouphael N, Suthar MS, Pulendran B. Arunachalam PS, et al. Among authors: feng y. medRxiv [Preprint]. 2022 Dec 4:2022.12.02.22282921. doi: 10.1101/2022.12.02.22282921. medRxiv. 2022. PMID: 36482977 Free PMC article. Updated. Preprint.
SREBP signaling is essential for effective B cell responses.
Luo W, Adamska JZ, Li C, Verma R, Liu Q, Hagan T, Wimmers F, Gupta S, Feng Y, Jiang W, Zhou J, Valore E, Wang Y, Trisal M, Subramaniam S, Osborne TF, Pulendran B. Luo W, et al. Among authors: feng y. Nat Immunol. 2023 Feb;24(2):337-348. doi: 10.1038/s41590-022-01376-y. Epub 2022 Dec 28. Nat Immunol. 2023. PMID: 36577930 Free PMC article.
Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2.
Feng Y, Yuan M, Powers JM, Hu M, Munt JE, Arunachalam PS, Leist SR, Bellusci L, Adams LE, Sundaramurthy S, Shirreff LM, Mallory ML, Scooby TD, Moreno A, O'Hagan DT, Kleanthous H, Villinger FJ, Veesler D, King NP, Suthar MS, Khurana S, Baric RS, Wilson IA, Pulendran B. Feng Y, et al. bioRxiv [Preprint]. 2023 Jan 20:2023.01.19.524784. doi: 10.1101/2023.01.19.524784. bioRxiv. 2023. PMID: 36711543 Free PMC article. Preprint.
Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life.
Wimmers F, Burrell AR, Feng Y, Zheng H, Arunachalam PS, Hu M, Spranger S, Nyhoff L, Joshi D, Trisal M, Awasthi M, Bellusci L, Ashraf U, Kowli S, Konvinse KC, Yang E, Blanco M, Pellegrini K, Tharp G, Hagan T, Chinthrajah RS, Grifoni A, Sette A, Nadeau KC, Haslam DB, Bosinger SE, Wrammert J, Maecker HT, Utz PJ, Wang TT, Khurana S, Khatri P, Staat MA, Pulendran B. Wimmers F, et al. Among authors: feng y. medRxiv [Preprint]. 2023 Jan 31:2023.01.28.23285133. doi: 10.1101/2023.01.28.23285133. medRxiv. 2023. PMID: 36778389 Free PMC article. Preprint.
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