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USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Gan J, Pinto-Fernández A, Flierman D, Akkermans JJLL, O'Brien DP, Greenwood H, Scott HC, Fritz G, Knobeloch KP, Neefjes J, van Dam H, Ovaa H, Ploegh HL, Kessler BM, Geurink PP, Sapmaz A. Gan J, et al. Among authors: flierman d. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055744
Development of a DUB-selective fluorogenic substrate.
Gjonaj L, Sapmaz A, Flierman D, Janssen GMC, van Veelen PA, Ovaa H. Gjonaj L, et al. Among authors: flierman d. Chem Sci. 2019 Sep 30;10(44):10290-10296. doi: 10.1039/c9sc02226k. eCollection 2019 Nov 28. Chem Sci. 2019. PMID: 32110315 Free PMC article.
USP7: combining tools towards selectivity.
Gjonaj L , Sapmaz A , González-Prieto R , Vertegaal ACO , Flierman D , Ovaa H . Gjonaj L , et al. Among authors: flierman d. Chem Commun (Camb). 2019 Apr 25;55(35):5075-5078. doi: 10.1039/c9cc00969h. Chem Commun (Camb). 2019. PMID: 30972393
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