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The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.
Peacock TP, Goldhill DH, Zhou J, Baillon L, Frise R, Swann OC, Kugathasan R, Penn R, Brown JC, Sanchez-David RY, Braga L, Williamson MK, Hassard JA, Staller E, Hanley B, Osborn M, Giacca M, Davidson AD, Matthews DA, Barclay WS. Peacock TP, et al. Among authors: goldhill dh. Nat Microbiol. 2021 Jul;6(7):899-909. doi: 10.1038/s41564-021-00908-w. Epub 2021 Apr 27. Nat Microbiol. 2021. PMID: 33907312
The mechanism of resistance to favipiravir in influenza.
Goldhill DH, Te Velthuis AJW, Fletcher RA, Langat P, Zambon M, Lackenby A, Barclay WS. Goldhill DH, et al. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11613-11618. doi: 10.1073/pnas.1811345115. Epub 2018 Oct 23. Proc Natl Acad Sci U S A. 2018. PMID: 30352857 Free PMC article.
ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells.
Staller E, Sheppard CM, Neasham PJ, Mistry B, Peacock TP, Goldhill DH, Long JS, Barclay WS. Staller E, et al. Among authors: goldhill dh. J Virol. 2019 Aug 13;93(17):e00217-19. doi: 10.1128/JVI.00217-19. Print 2019 Sep 1. J Virol. 2019. PMID: 31217244 Free PMC article.
Swine ANP32A Supports Avian Influenza Virus Polymerase.
Peacock TP, Swann OC, Salvesen HA, Staller E, Leung PB, Goldhill DH, Zhou H, Lillico SG, Whitelaw CBA, Long JS, Barclay WS. Peacock TP, et al. Among authors: goldhill dh. J Virol. 2020 Jun 1;94(12):e00132-20. doi: 10.1128/JVI.00132-20. Print 2020 Jun 1. J Virol. 2020. PMID: 32269123 Free PMC article.
Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission.
Lee LYY, Zhou J, Frise R, Goldhill DH, Koszalka P, Mifsud EJ, Baba K, Noda T, Ando Y, Sato K, Yuki AI, Shishido T, Uehara T, Wildum S, Zwanziger E, Collinson N, Kuhlbusch K, Clinch B, Hurt AC, Barclay WS. Lee LYY, et al. Among authors: goldhill dh. PLoS Pathog. 2020 Apr 15;16(4):e1008395. doi: 10.1371/journal.ppat.1008395. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32294137 Free PMC article.
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia.
Braga L, Ali H, Secco I, Chiavacci E, Neves G, Goldhill D, Penn R, Jimenez-Guardeño JM, Ortega-Prieto AM, Bussani R, Cannatà A, Rizzari G, Collesi C, Schneider E, Arosio D, Shah AM, Barclay WS, Malim MH, Burrone J, Giacca M. Braga L, et al. Nature. 2021 Jun;594(7861):88-93. doi: 10.1038/s41586-021-03491-6. Epub 2021 Apr 7. Nature. 2021. PMID: 33827113 Free PMC article.
Favipiravir-resistant influenza A virus shows potential for transmission.
Goldhill DH, Yan A, Frise R, Zhou J, Shelley J, Gallego Cortés A, Miah S, Akinbami O, Galiano M, Zambon M, Lackenby A, Barclay WS. Goldhill DH, et al. PLoS Pathog. 2021 Jun 1;17(6):e1008937. doi: 10.1371/journal.ppat.1008937. eCollection 2021 Jun. PLoS Pathog. 2021. PMID: 34061908 Free PMC article.
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