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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials.
Happe M, Hofstetter AR, Wang J, Yamshchikov GV, Holman LA, Novik L, Strom L, Kiweewa F, Wakabi S, Millard M, Kelley CF, Kabbani S, Edupuganti S, Beck A, Kaltovich F, Murray T, Tsukerman S, Carr D, Ashman C, Stanley DA, Ploquin A, Bailer RT, Schwartz R, Cham F, Tindikahwa A, Hu Z, Gordon IJ, Rouphael N, Houser KV, Coates EE, Graham BS, Koup RA, Mascola JR, Sullivan NJ, Robb ML, Ake JA, Lyke KE, Mulligan MJ, Ledgerwood JE, Kibuuka H; VRC 208 and RV 422 study team. Happe M, et al. Among authors: graham bs. NPJ Vaccines. 2024 Mar 29;9(1):67. doi: 10.1038/s41541-024-00833-z. NPJ Vaccines. 2024. PMID: 38553525 Free PMC article.
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M. Lederhofer J, et al. Among authors: graham bs. Immunity. 2024 Mar 12;57(3):574-586.e7. doi: 10.1016/j.immuni.2024.02.003. Epub 2024 Mar 1. Immunity. 2024. PMID: 38430907 Free article.
Prefusion stabilization of the Hendra and Langya virus F proteins.
Byrne PO, Blade EG, Fisher BE, Ambrozak DR, Ramamohan AR, Graham BS, Loomis RJ, McLellan JS. Byrne PO, et al. Among authors: graham bs. J Virol. 2024 Feb 20;98(2):e0137223. doi: 10.1128/jvi.01372-23. Epub 2024 Jan 12. J Virol. 2024. PMID: 38214525 Free PMC article.
Antigen spacing on protein nanoparticles influences antibody responses to vaccination.
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP. Ellis D, et al. Among authors: graham bs. Cell Rep. 2023 Dec 26;42(12):113552. doi: 10.1016/j.celrep.2023.113552. Epub 2023 Dec 13. Cell Rep. 2023. PMID: 38096058 Free PMC article.
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera.
Hutchinson GB, Abiona OM, Ziwawo CT, Werner AP, Ellis D, Tsybovsky Y, Leist SR, Palandjian C, West A, Fritch EJ, Wang N, Wrapp D, Boyoglu-Barnum S, Ueda G, Baker D, Kanekiyo M, McLellan JS, Baric RS, King NP, Graham BS, Corbett-Helaire KS. Hutchinson GB, et al. Among authors: graham bs. Nat Commun. 2023 Oct 4;14(1):6195. doi: 10.1038/s41467-023-41661-4. Nat Commun. 2023. PMID: 37794071 Free PMC article.
Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures.
Kanekiyo M, Gillespie RA, Midgett M, O'Malley KJ, Williams C, Moin SM, Wallace M, Treaster L, Cooper K, Syeda H, Kettenburg G, Rannulu H, Schmer T, Ortiz L, Da Silva Castanha P, Corry J, Xia M, Olsen E, Perez D, Yun G, Graham BS, Barratt-Boyes SM, Reed DS. Kanekiyo M, et al. Among authors: graham bs. iScience. 2023 Sep 6;26(10):107830. doi: 10.1016/j.isci.2023.107830. eCollection 2023 Oct 20. iScience. 2023. PMID: 37766976 Free PMC article.
Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses.
Ols S, Lenart K, Arcoverde Cerveira R, Miranda MC, Brunette N, Kochmann J, Corcoran M, Skotheim R, Philomin A, Cagigi A, Fiala B, Wrenn S, Marcandalli J, Hellgren F, Thompson EA, Lin A, Gegenfurtner F, Kumar A, Chen M, Phad GE, Graham BS, Perez L, Borst AJ, Karlsson Hedestam GB, Ruckwardt TJ, King NP, Loré K. Ols S, et al. Among authors: graham bs. Immunity. 2023 Oct 10;56(10):2425-2441.e14. doi: 10.1016/j.immuni.2023.08.011. Epub 2023 Sep 8. Immunity. 2023. PMID: 37689061 Free article.
578 results