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Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens.
PLoS One. 2013;8(1):e54613. doi: 10.1371/journal.pone.0054613. Epub 2013 Jan 28.
PLoS One. 2013.
PMID: 23382923
Free PMC article.
Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen.
Wu X, Subramaniam M, Grygo SB, Sun Z, Negron V, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC, Hawse JR.
Wu X, et al. Among authors: grygo sb.
Breast Cancer Res. 2011 Mar 10;13(2):R27. doi: 10.1186/bcr2844.
Breast Cancer Res. 2011.
PMID: 21392396
Free PMC article.
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TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts.
Hawse JR, Cicek M, Grygo SB, Bruinsma ES, Rajamannan NM, van Wijnen AJ, Lian JB, Stein GS, Oursler MJ, Subramaniam M, Spelsberg TC.
Hawse JR, et al. Among authors: grygo sb.
PLoS One. 2011 Apr 29;6(4):e19429. doi: 10.1371/journal.pone.0019429.
PLoS One. 2011.
PMID: 21559363
Free PMC article.
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TGFbeta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts.
Subramaniam M, Hawse JR, Bruinsma ES, Grygo SB, Cicek M, Oursler MJ, Spelsberg TC.
Subramaniam M, et al. Among authors: grygo sb.
Biochem Biophys Res Commun. 2010 Jan 29;392(1):72-6. doi: 10.1016/j.bbrc.2009.12.171. Epub 2010 Jan 6.
Biochem Biophys Res Commun. 2010.
PMID: 20059964
Free PMC article.
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