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Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, Al-Saraj S, Killick R, Pickering-Brown S, Moore P, Hollingworth P, Archer N, Foy C, Walter S, Lendon C, Iwatsubo T, Morris JC, Norton J, Mann D, Janssens B, Hardy J, O'Donovan M, Jones L, Williams J, Holmans P, Owen MJ, Grupe A, Powell J, van Hengel J, Goate A, Van Roy F, Lovestone S. Busby V, et al. Among authors: hamilton g. Neuromolecular Med. 2004;5(2):133-46. doi: 10.1385/NMM:5:2:133. Neuromolecular Med. 2004. PMID: 15075440
Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J. Morgan AR, et al. Among authors: hamilton g. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144B(6):762-70. doi: 10.1002/ajmg.b.30509. Am J Med Genet B Neuropsychiatr Genet. 2007. PMID: 17373700
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. Grupe A, et al. Among authors: hamilton g. Am J Hum Genet. 2006 Jan;78(1):78-88. doi: 10.1086/498851. Epub 2005 Nov 15. Am J Hum Genet. 2006. PMID: 16385451 Free PMC article.
Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease.
Morgan AR, Hamilton G, Turic D, Jehu L, Harold D, Abraham R, Hollingworth P, Moskvina V, Brayne C, Rubinsztein DC, Lynch A, Lawlor B, Gill M, O'Donovan M, Powell J, Lovestone S, Williams J, Owen MJ. Morgan AR, et al. Among authors: hamilton g. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):727-31. doi: 10.1002/ajmg.b.30670. Am J Med Genet B Neuropsychiatr Genet. 2008. PMID: 18163421
Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.
Lupton MK, Proitsi P, Danillidou M, Tsolaki M, Hamilton G, Wroe R, Pritchard M, Lord K, Martin BM, Kloszewska I, Soininen H, Mecocci P, Vellas B, Harold D, Hollingworth P, Lovestone S, Powell JF. Lupton MK, et al. Among authors: hamilton g. PLoS One. 2011 Feb 25;6(2):e17298. doi: 10.1371/journal.pone.0017298. PLoS One. 2011. PMID: 21364883 Free PMC article.
1,673 results