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Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial.
Koch T, Dahlke C, Fathi A, Kupke A, Krähling V, Okba NMA, Halwe S, Rohde C, Eickmann M, Volz A, Hesterkamp T, Jambrecina A, Borregaard S, Ly ML, Zinser ME, Bartels E, Poetsch JSH, Neumann R, Fux R, Schmiedel S, Lohse AW, Haagmans BL, Sutter G, Becker S, Addo MM. Koch T, et al. Among authors: hesterkamp t. Lancet Infect Dis. 2020 Jul;20(7):827-838. doi: 10.1016/S1473-3099(20)30248-6. Epub 2020 Apr 21. Lancet Infect Dis. 2020. PMID: 32325037 Free PMC article. Clinical Trial.
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome.
Fathi A, Dahlke C, Krähling V, Kupke A, Okba NMA, Raadsen MP, Heidepriem J, Müller MA, Paris G, Lassen S, Klüver M, Volz A, Koch T, Ly ML, Friedrich M, Fux R, Tscherne A, Kalodimou G, Schmiedel S, Corman VM, Hesterkamp T, Drosten C, Loeffler FF, Haagmans BL, Sutter G, Becker S, Addo MM. Fathi A, et al. Among authors: hesterkamp t. Nat Commun. 2022 Jul 19;13(1):4182. doi: 10.1038/s41467-022-31557-0. Nat Commun. 2022. PMID: 35853863 Free PMC article.
Novel MK2 inhibitors by fragment screening.
Keminer O, Kraemer J, Kahmann J, Sternberger I, Scheich C, Jungmann J, Schaert S, Winkler D, Ichihara O, Whittaker M, Ullmann D, Hesterkamp T. Keminer O, et al. Among authors: hesterkamp t. Comb Chem High Throughput Screen. 2009 Aug;12(7):697-703. doi: 10.2174/138620709788923700. Epub 2009 Aug 1. Comb Chem High Throughput Screen. 2009. PMID: 19531016
Fragment-based activity space: smaller is better.
Hesterkamp T, Whittaker M. Hesterkamp T, et al. Curr Opin Chem Biol. 2008 Jun;12(3):260-8. doi: 10.1016/j.cbpa.2008.02.005. Epub 2008 Mar 19. Curr Opin Chem Biol. 2008. PMID: 18316043 Review.
Fragment-based identification of Hsp90 inhibitors.
Barker JJ, Barker O, Boggio R, Chauhan V, Cheng RK, Corden V, Courtney SM, Edwards N, Falque VM, Fusar F, Gardiner M, Hamelin EM, Hesterkamp T, Ichihara O, Jones RS, Mather O, Mercurio C, Minucci S, Montalbetti CA, Müller A, Patel D, Phillips BG, Varasi M, Whittaker M, Winkler D, Yarnold CJ. Barker JJ, et al. Among authors: hesterkamp t. ChemMedChem. 2009 Jun;4(6):963-6. doi: 10.1002/cmdc.200900011. ChemMedChem. 2009. PMID: 19301319
Fragment screening by biochemical assay.
Barker J, Courtney S, Hesterkamp T, Ullmann D, Whittaker M. Barker J, et al. Among authors: hesterkamp t. Expert Opin Drug Discov. 2006 Aug;1(3):225-36. doi: 10.1517/17460441.1.3.225. Expert Opin Drug Discov. 2006. PMID: 23495844
A multiplexed approach to hit finding.
Slack M, Winkler D, Krämer J, Hesterkamp T. Slack M, et al. Among authors: hesterkamp t. Curr Opin Drug Discov Devel. 2009 May;12(3):351-7. Curr Opin Drug Discov Devel. 2009. PMID: 19396736 Review.
Fragment-based discovery and optimization of BACE1 inhibitors.
Madden J, Dod JR, Godemann R, Kraemer J, Smith M, Biniszkiewicz M, Hallett DJ, Barker J, Dyekjaer JD, Hesterkamp T. Madden J, et al. Among authors: hesterkamp t. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5329-33. doi: 10.1016/j.bmcl.2010.06.089. Epub 2010 Jun 27. Bioorg Med Chem Lett. 2010. PMID: 20656487
41 results