Hilgenfeld R - Search Results

1

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors.

Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, Becker S, Rox K, Hilgenfeld R. Zhang L, et al. Among authors: hilgenfeld r. Science. 2020 Apr 24;368(6489):409-412. doi: 10.1126/science.abb3405. Epub 2020 Mar 20. Science. 2020. PMID: 32198291 Free PMC article.

2

A common core for binding single-stranded DNA: structural comparison of the single-stranded DNA-binding proteins (SSB) from E. coli and human mitochondria.

Webster G, Genschel J, Curth U, Urbanke C, Kang C, Hilgenfeld R. Webster G, et al. Among authors: hilgenfeld r. FEBS Lett. 1997 Jul 14;411(2-3):313-6. doi: 10.1016/s0014-5793(97)00747-3. FEBS Lett. 1997. PMID: 9271227 Free article.

3

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.

Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Anand K, et al. Among authors: hilgenfeld r. Science. 2003 Jun 13;300(5626):1763-7. doi: 10.1126/science.1085658. Epub 2003 May 13. Science. 2003. PMID: 12746549

4

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor.

Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. Yang H, et al. Among authors: hilgenfeld r. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-5. doi: 10.1073/pnas.1835675100. Epub 2003 Oct 29. Proc Natl Acad Sci U S A. 2003. PMID: 14585926 Free PMC article.

5

Design of wide-spectrum inhibitors targeting coronavirus main proteases.

Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen KY, Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M, Rao Z. Yang H, et al. Among authors: hilgenfeld r. PLoS Biol. 2005 Oct;3(10):e324. doi: 10.1371/journal.pbio.0030324. Epub 2005 Sep 6. PLoS Biol. 2005. PMID: 16128623 Free PMC article.

6

Structure and dynamics of SARS coronavirus main proteinase (Mpro).

Hilgenfeld R, Anand K, Mesters JR, Rao Z, Shen X, Jiang H, Tan J, Verschueren KH. Hilgenfeld R, et al. Adv Exp Med Biol. 2006;581:585-91. doi: 10.1007/978-0-387-33012-9_106. Adv Exp Med Biol. 2006. PMID: 17037602 Free PMC article. No abstract available.

7

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters.

Verschueren KH, Pumpor K, Anemüller S, Chen S, Mesters JR, Hilgenfeld R. Verschueren KH, et al. Among authors: hilgenfeld r. Chem Biol. 2008 Jun;15(6):597-606. doi: 10.1016/j.chembiol.2008.04.011. Chem Biol. 2008. PMID: 18559270 Free PMC article.

8

Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode.

Chen S, Jonas F, Shen C, Hilgenfeld R. Chen S, et al. Among authors: hilgenfeld r. Protein Cell. 2010 Jan;1(1):59-74. doi: 10.1007/s13238-010-0011-4. Epub 2010 Feb 7. Protein Cell. 2010. PMID: 21203998 Free PMC article.

9

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.

Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R. Zhu L, et al. Among authors: hilgenfeld r. Antiviral Res. 2011 Nov;92(2):204-12. doi: 10.1016/j.antiviral.2011.08.001. Epub 2011 Aug 11. Antiviral Res. 2011. PMID: 21854807 Free PMC article.

10

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.

Pfefferle S, Schöpf J, Kögl M, Friedel CC, Müller MA, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Kallies S, Niemeyer D, Ditt V, Kuri T, Züst R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, Pöhlmann S, Haas J, Drosten C, von Brunn A. Pfefferle S, et al. Among authors: hilgenfeld r. PLoS Pathog. 2011 Oct;7(10):e1002331. doi: 10.1371/journal.ppat.1002331. Epub 2011 Oct 27. PLoS Pathog. 2011. PMID: 22046132 Free PMC article.

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