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Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures.
Hui KPY, Cheung MC, Perera RAPM, Ng KC, Bui CHT, Ho JCW, Ng MMT, Kuok DIT, Shih KC, Tsao SW, Poon LLM, Peiris M, Nicholls JM, Chan MCW. Hui KPY, et al. Among authors: ho jcw. Lancet Respir Med. 2020 Jul;8(7):687-695. doi: 10.1016/S2213-2600(20)30193-4. Epub 2020 May 7. Lancet Respir Med. 2020. PMID: 32386571 Free PMC article.
Tropism of SARS-CoV-2, SARS-CoV, and Influenza Virus in Canine Tissue Explants.
Bui CHT, Yeung HW, Ho JCW, Leung CYH, Hui KPY, Perera RAPM, Webby RJ, Schultz-Cherry SL, Nicholls JM, Peiris JSM, Chan MCW. Bui CHT, et al. Among authors: ho jcw. J Infect Dis. 2021 Sep 1;224(5):821-830. doi: 10.1093/infdis/jiab002. J Infect Dis. 2021. PMID: 33395484 Free PMC article.
SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo.
Hui KPY, Ho JCW, Cheung MC, Ng KC, Ching RHH, Lai KL, Kam TT, Gu H, Sit KY, Hsin MKY, Au TWK, Poon LLM, Peiris M, Nicholls JM, Chan MCW. Hui KPY, et al. Among authors: ho jcw. Nature. 2022 Mar;603(7902):715-720. doi: 10.1038/s41586-022-04479-6. Epub 2022 Feb 1. Nature. 2022. PMID: 35104836
Amino acid substitution L232F in non-structural protein 6 identified as a possible human-adaptive mutation in clade B MERS coronaviruses.
So RTY, Chu DKW, Hui KPY, Mok CKP, Shum MHH, Sanyal S, Nicholls JM, Ho JCW, Cheung M-c, Ng K-c, Yeung H-W, Chan MCW, Poon LLM, Zhao J, Lam TTY, Peiris M. So RTY, et al. Among authors: ho jcw. J Virol. 2023 Dec 21;97(12):e0136923. doi: 10.1128/jvi.01369-23. Epub 2023 Dec 1. J Virol. 2023. PMID: 38038429 Free PMC article.
Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo.
So RT, Chu DK, Hui KP, Mok CK, Sanyal S, Nicholls JM, Ho JCW, Cheung MC, Ng KC, Yeung HW, Chan MC, Poon LL, Zhao J, Peiris M. So RT, et al. Among authors: ho jcw. bioRxiv [Preprint]. 2023 Mar 28:2023.03.27.534490. doi: 10.1101/2023.03.27.534490. bioRxiv. 2023. PMID: 37034576 Free PMC article. Updated. Preprint.
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL. Lo HS, et al. Among authors: ho jcw. ACS Cent Sci. 2021 May 26;7(5):792-802. doi: 10.1021/acscentsci.0c01186. Epub 2021 Apr 15. ACS Cent Sci. 2021. PMID: 34075346 Free PMC article.
21 results