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Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.
Leeds JM, Fenneteau F, Gosselin NH, Mouksassi MS, Kassir N, Marier JF, Chen Y, Grosenbach D, Frimm AE, Honeychurch KM, Chinsangaram J, Tyavanagimatt SR, Hruby DE, Jordan R. Leeds JM, et al. Among authors: hruby de. Antimicrob Agents Chemother. 2013 Mar;57(3):1136-43. doi: 10.1128/AAC.00959-12. Epub 2012 Dec 17. Antimicrob Agents Chemother. 2013. PMID: 23254433 Free PMC article.
Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.
Berhanu A, Prigge JT, Silvera PM, Honeychurch KM, Hruby DE, Grosenbach DW. Berhanu A, et al. Among authors: hruby de. Antimicrob Agents Chemother. 2015 Jul;59(7):4296-300. doi: 10.1128/AAC.00208-15. Epub 2015 Apr 20. Antimicrob Agents Chemother. 2015. PMID: 25896687 Free PMC article.
Oral Tecovirimat for the Treatment of Smallpox.
Grosenbach DW, Honeychurch K, Rose EA, Chinsangaram J, Frimm A, Maiti B, Lovejoy C, Meara I, Long P, Hruby DE. Grosenbach DW, et al. Among authors: hruby de. N Engl J Med. 2018 Jul 5;379(1):44-53. doi: 10.1056/NEJMoa1705688. N Engl J Med. 2018. PMID: 29972742 Free PMC article. Clinical Trial.
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.
Grosenbach DW, Berhanu A, King DS, Mosier S, Jones KF, Jordan RA, Bolken TC, Hruby DE. Grosenbach DW, et al. Among authors: hruby de. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):838-43. doi: 10.1073/pnas.0912134107. Epub 2009 Dec 22. Proc Natl Acad Sci U S A. 2010. PMID: 20080762 Free PMC article.
215 results