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SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.
Agerer B, Koblischke M, Gudipati V, Montaño-Gutierrez LF, Smyth M, Popa A, Genger JW, Endler L, Florian DM, Mühlgrabner V, Graninger M, Aberle SW, Husa AM, Shaw LE, Lercher A, Gattinger P, Torralba-Gombau R, Trapin D, Penz T, Barreca D, Fae I, Wenda S, Traugott M, Walder G, Pickl WF, Thiel V, Allerberger F, Stockinger H, Puchhammer-Stöckl E, Weninger W, Fischer G, Hoepler W, Pawelka E, Zoufaly A, Valenta R, Bock C, Paster W, Geyeregger R, Farlik M, Halbritter F, Huppa JB, Aberle JH, Bergthaler A. Agerer B, et al. Among authors: huppa jb. Sci Immunol. 2021 Mar 4;6(57):eabg6461. doi: 10.1126/sciimmunol.abg6461. Sci Immunol. 2021. PMID: 33664060 Free PMC article.
RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.
Salzer E, Cagdas D, Hons M, Mace EM, Garncarz W, Petronczki ÖY, Platzer R, Pfajfer L, Bilic I, Ban SA, Willmann KL, Mukherjee M, Supper V, Hsu HT, Banerjee PP, Sinha P, McClanahan F, Zlabinger GJ, Pickl WF, Gribben JG, Stockinger H, Bennett KL, Huppa JB, Dupré L, Sanal Ö, Jäger U, Sixt M, Tezcan I, Orange JS, Boztug K. Salzer E, et al. Among authors: huppa jb. Nat Immunol. 2016 Dec;17(12):1352-1360. doi: 10.1038/ni.3575. Epub 2016 Oct 24. Nat Immunol. 2016. PMID: 27776107 Free PMC article.
A cellular platform for the evaluation of immune checkpoint molecules.
Jutz S, Hennig A, Paster W, Asrak Ö, Dijanovic D, Kellner F, Pickl WF, Huppa JB, Leitner J, Steinberger P. Jutz S, et al. Among authors: huppa jb. Oncotarget. 2017 May 4;8(39):64892-64906. doi: 10.18632/oncotarget.17615. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29029399 Free PMC article.
Monomeric TCRs drive T cell antigen recognition.
Brameshuber M, Kellner F, Rossboth BK, Ta H, Alge K, Sevcsik E, Göhring J, Axmann M, Baumgart F, Gascoigne NRJ, Davis SJ, Stockinger H, Schütz GJ, Huppa JB. Brameshuber M, et al. Among authors: huppa jb. Nat Immunol. 2018 May;19(5):487-496. doi: 10.1038/s41590-018-0092-4. Epub 2018 Apr 16. Nat Immunol. 2018. PMID: 29662172 Free PMC article.
Mutations affecting the actin regulator WD repeat-containing protein 1 lead to aberrant lymphoid immunity.
Pfajfer L, Mair NK, Jiménez-Heredia R, Genel F, Gulez N, Ardeniz Ö, Hoeger B, Bal SK, Madritsch C, Kalinichenko A, Chandra Ardy R, Gerçeker B, Rey-Barroso J, Ijspeert H, Tangye SG, Simonitsch-Klupp I, Huppa JB, van der Burg M, Dupré L, Boztug K. Pfajfer L, et al. Among authors: huppa jb. J Allergy Clin Immunol. 2018 Nov;142(5):1589-1604.e11. doi: 10.1016/j.jaci.2018.04.023. Epub 2018 May 8. J Allergy Clin Immunol. 2018. PMID: 29751004 Free article.
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Ohradanova-Repic A, Machacek C, Charvet C, Lager F, Le Roux D, Platzer R, Leksa V, Mitulovic G, Burkard TR, Zlabinger GJ, Fischer MB, Feuillet V, Renault G, Blüml S, Benko M, Suchanek M, Huppa JB, Matsuyama T, Cavaco-Paulo A, Bismuth G, Stockinger H. Ohradanova-Repic A, et al. Among authors: huppa jb. Front Immunol. 2018 Apr 27;9:852. doi: 10.3389/fimmu.2018.00852. eCollection 2018. Front Immunol. 2018. PMID: 29780382 Free PMC article.
Inefficient CAR-proximal signaling blunts antigen sensitivity.
Gudipati V, Rydzek J, Doel-Perez I, Gonçalves VDR, Scharf L, Königsberger S, Lobner E, Kunert R, Einsele H, Stockinger H, Hudecek M, Huppa JB. Gudipati V, et al. Among authors: huppa jb. Nat Immunol. 2020 Aug;21(8):848-856. doi: 10.1038/s41590-020-0719-0. Epub 2020 Jul 6. Nat Immunol. 2020. PMID: 32632291
72 results