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Understanding the treatment benefit of hyperimmune anti-influenza intravenous immunoglobulin (Flu-IVIG) for severe human influenza.
Vanderven HA, Wentworth DN, Han WM, Peck H, Barr IG, Davey RT Jr, Beigel JH, Dwyer DE, Jain MK, Angus B, Brandt CT, Mykietiuk A, Law MG, Neaton JD, Kent SJ; INSIGHT FLU-IVIG Study Group. Vanderven HA, et al. JCI Insight. 2023 Jul 24;8(14):e167464. doi: 10.1172/jci.insight.167464. JCI Insight. 2023. PMID: 37289541 Free PMC article.
Comparison of an ordinal endpoint to time-to-event, longitudinal, and binary endpoints for use in evaluating treatments for severe influenza requiring hospitalization.
Peterson RL, Vock DM, Babiker A, Powers JH 3rd, Hunsberger S, Angus B, Paez A, Neaton JD; INSIGHT FLU-IVIG study group. Peterson RL, et al. Contemp Clin Trials Commun. 2019 Jun 21;15:100401. doi: 10.1016/j.conctc.2019.100401. eCollection 2019 Sep. Contemp Clin Trials Commun. 2019. PMID: 31312748 Free PMC article.
Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial.
Davey RT Jr, Fernández-Cruz E, Markowitz N, Pett S, Babiker AG, Wentworth D, Khurana S, Engen N, Gordin F, Jain MK, Kan V, Polizzotto MN, Riska P, Ruxrungtham K, Temesgen Z, Lundgren J, Beigel JH, Lane HC, Neaton JD; INSIGHT FLU-IVIG Study Group. Davey RT Jr, et al. Lancet Respir Med. 2019 Nov;7(11):951-963. doi: 10.1016/S2213-2600(19)30253-X. Epub 2019 Sep 30. Lancet Respir Med. 2019. PMID: 31582358 Free PMC article. Clinical Trial.