Isom LL - Search Results

1

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome.

Han Z, Chen C, Christiansen A, Ji S, Lin Q, Anumonwo C, Liu C, Leiser SC, Meena, Aznarez I, Liau G, Isom LL. Han Z, et al. Among authors: isom ll. Sci Transl Med. 2020 Aug 26;12(558):eaaz6100. doi: 10.1126/scitranslmed.aaz6100. Sci Transl Med. 2020. PMID: 32848094

2

Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes.

Dhar Malhotra J, Chen C, Rivolta I, Abriel H, Malhotra R, Mattei LN, Brosius FC, Kass RS, Isom LL. Dhar Malhotra J, et al. Among authors: isom ll. Circulation. 2001 Mar 6;103(9):1303-10. doi: 10.1161/01.cir.103.9.1303. Circulation. 2001. PMID: 11238277

3

Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin.

McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL. McEwen DP, et al. Among authors: isom ll. J Biol Chem. 2004 Apr 16;279(16):16044-9. doi: 10.1074/jbc.M400856200. Epub 2004 Feb 3. J Biol Chem. 2004. PMID: 14761957 Free article.

4

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.

Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL. Chen C, et al. Among authors: isom ll. J Neurosci. 2004 Apr 21;24(16):4030-42. doi: 10.1523/JNEUROSCI.4139-03.2004. J Neurosci. 2004. PMID: 15102918 Free PMC article.

5

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

Malhotra JD, Thyagarajan V, Chen C, Isom LL. Malhotra JD, et al. Among authors: isom ll. J Biol Chem. 2004 Sep 24;279(39):40748-54. doi: 10.1074/jbc.M407243200. Epub 2004 Jul 21. J Biol Chem. 2004. PMID: 15272007 Free article.

6

Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons.

Davis TH, Chen C, Isom LL. Davis TH, et al. Among authors: isom ll. J Biol Chem. 2004 Dec 3;279(49):51424-32. doi: 10.1074/jbc.M410830200. Epub 2004 Sep 27. J Biol Chem. 2004. PMID: 15452131 Free article.

7

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

Lopez-Santiago LF, Pertin M, Morisod X, Chen C, Hong S, Wiley J, Decosterd I, Isom LL. Lopez-Santiago LF, et al. Among authors: isom ll. J Neurosci. 2006 Jul 26;26(30):7984-94. doi: 10.1523/JNEUROSCI.2211-06.2006. J Neurosci. 2006. PMID: 16870743 Free PMC article.

8

Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant.

Fein AJ, Meadows LS, Chen C, Slat EA, Isom LL. Fein AJ, et al. Among authors: isom ll. BMC Genomics. 2007 Jul 10;8:226. doi: 10.1186/1471-2164-8-226. BMC Genomics. 2007. PMID: 17623064 Free PMC article.

9

Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b.

Chen C, Dickendesher TL, Oyama F, Miyazaki H, Nukina N, Isom LL. Chen C, et al. Among authors: isom ll. Genesis. 2007 Sep;45(9):547-53. doi: 10.1002/dvg.20324. Genesis. 2007. PMID: 17868089 Free article.

10

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. Lopez-Santiago LF, et al. Among authors: isom ll. J Mol Cell Cardiol. 2007 Nov;43(5):636-47. doi: 10.1016/j.yjmcc.2007.07.062. Epub 2007 Aug 10. J Mol Cell Cardiol. 2007. PMID: 17884088 Free PMC article.

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