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Human TCR-binding affinity is governed by MHC class restriction.
Cole DK, Pumphrey NJ, Boulter JM, Sami M, Bell JI, Gostick E, Price DA, Gao GF, Sewell AK, Jakobsen BK. Cole DK, et al. Among authors: jakobsen bk. J Immunol. 2007 May 1;178(9):5727-34. doi: 10.4049/jimmunol.178.9.5727. J Immunol. 2007. PMID: 17442956
Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC.
Cole DK, Rizkallah PJ, Sami M, Lissin NM, Gao F, Bell JI, Boulter JM, Glick M, Vuidepot AL, Jakobsen BK, Gao GF. Cole DK, et al. Among authors: jakobsen bk. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt 3):285-7. doi: 10.1107/S1744309105002988. Epub 2005 Feb 12. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511019 Free PMC article.
Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.
Yuan F, Georgiou T, Hillon T, Gostick E, Price DA, Sewell AK, Moysey R, Gavarret J, Vuidepot A, Sami M, Bell JI, Gao GF, Rizkallah PJ, Jakobsen BK. Yuan F, et al. Among authors: jakobsen bk. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1;63(Pt 9):758-60. doi: 10.1107/S1744309107037244. Epub 2007 Aug 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17768347 Free PMC article.
The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.
Purbhoo MA, Boulter JM, Price DA, Vuidepot AL, Hourigan CS, Dunbar PR, Olson K, Dawson SJ, Phillips RE, Jakobsen BK, Bell JI, Sewell AK. Purbhoo MA, et al. Among authors: jakobsen bk. J Biol Chem. 2001 Aug 31;276(35):32786-92. doi: 10.1074/jbc.M102498200. Epub 2001 Jul 3. J Biol Chem. 2001. PMID: 11438524 Free article.
Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.
Sewell AK, Gerth UC, Price DA, Purbhoo MA, Boulter JM, Gao GF, Bell JI, Phillips RE, Jakobsen BK. Sewell AK, et al. Among authors: jakobsen bk. Nat Med. 1999 Apr;5(4):399-404. doi: 10.1038/7398. Nat Med. 1999. PMID: 10202928
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
Glick M, Price DA, Vuidepot AL, Andersen TB, Hutchinson SL, Laugel B, Sewell AK, Boulter JM, Dunbar PR, Cerundolo V, Oxenius A, Bell JI, Richards WG, Jakobsen BK. Glick M, et al. Among authors: jakobsen bk. J Biol Chem. 2002 Jun 7;277(23):20840-6. doi: 10.1074/jbc.M201819200. Epub 2002 Mar 25. J Biol Chem. 2002. PMID: 11914379 Free article.
163 results