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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
Rappazzo CG, Tse LV, Kaku CI, Wrapp D, Sakharkar M, Huang D, Deveau LM, Yockachonis TJ, Herbert AS, Battles MB, O'Brien CM, Brown ME, Geoghegan JC, Belk J, Peng L, Yang L, Hou Y, Scobey TD, Burton DR, Nemazee D, Dye JM, Voss JE, Gunn BM, McLellan JS, Baric RS, Gralinski LE, Walker LM. Rappazzo CG, et al. Among authors: kaku ci. Science. 2021 Feb 19;371(6531):823-829. doi: 10.1126/science.abf4830. Epub 2021 Jan 25. Science. 2021. PMID: 33495307 Free PMC article.
An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19.
Rappazzo CG, Tse LV, Kaku CI, Wrapp D, Sakharkar M, Huang D, Deveau LM, Yockachonis TJ, Herbert AS, Battles MB, O'Brien CM, Brown ME, Geoghegan JC, Belk J, Peng L, Yang L, Scobey TD, Burton DR, Nemazee D, Dye JM, Voss JE, Gunn BM, McLellan JS, Baric RS, Gralinski LE, Walker LM. Rappazzo CG, et al. Among authors: kaku ci. bioRxiv [Preprint]. 2020 Nov 17:2020.11.17.385500. doi: 10.1101/2020.11.17.385500. bioRxiv. 2020. PMID: 33236009 Free PMC article. Preprint.
Prolonged evolution of the human B cell response to SARS-CoV-2 infection.
Sakharkar M, Rappazzo CG, Wieland-Alter WF, Hsieh CL, Wrapp D, Esterman ES, Kaku CI, Wec AZ, Geoghegan JC, McLellan JS, Connor RI, Wright PF, Walker LM. Sakharkar M, et al. Among authors: kaku ci. Sci Immunol. 2021 Feb 23;6(56):eabg6916. doi: 10.1126/sciimmunol.abg6916. Sci Immunol. 2021. PMID: 33622975 Free PMC article.
A broad and potent neutralization epitope in SARS-related coronaviruses.
Yuan M, Zhu X, He WT, Zhou P, Kaku CI, Capozzola T, Zhu CY, Yu X, Liu H, Yu W, Hua Y, Tien H, Peng L, Song G, Cottrell CA, Schief WR, Nemazee D, Walker LM, Andrabi R, Burton DR, Wilson IA. Yuan M, et al. Among authors: kaku ci. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2205784119. doi: 10.1073/pnas.2205784119. Epub 2022 Jun 29. Proc Natl Acad Sci U S A. 2022. PMID: 35767670 Free PMC article.
Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19.
Zumbrun EE, Kaku CI, Dillinger L, Zak SE, Kuehne AI, Bakken RR, Koehler JW, Delp KL, Stefan CP, Kumar R, Kugelman JR, Moreau AM, Zeng X, Dye JM, Herbert AS, Narayan K, Walker LM. Zumbrun EE, et al. Among authors: kaku ci. Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0135322. doi: 10.1128/aac.01353-22. Epub 2022 Dec 15. Antimicrob Agents Chemother. 2023. PMID: 36519929 Free PMC article.
Antibody-mediated protection against symptomatic COVID-19 can be achieved at low serum neutralizing titers.
Schmidt P, Narayan K, Li Y, Kaku CI, Brown ME, Champney E, Geoghegan JC, Vásquez M, Krauland EM, Yockachonis T, Bai S, Gunn BM, Cammarata A, Rubino CM, Ambrose P, Walker LM. Schmidt P, et al. Among authors: kaku ci. Sci Transl Med. 2023 Mar 22;15(688):eadg2783. doi: 10.1126/scitranslmed.adg2783. Epub 2023 Mar 22. Sci Transl Med. 2023. PMID: 36947596 Free article.
Evolution of antibody immunity following Omicron BA.1 breakthrough infection.
Kaku CI, Starr TN, Zhou P, Dugan HL, Khalifé P, Song G, Champney ER, Mielcarz DW, Geoghegan JC, Burton DR, Andrabi R, Bloom JD, Walker LM. Kaku CI, et al. Nat Commun. 2023 May 12;14(1):2751. doi: 10.1038/s41467-023-38345-4. Nat Commun. 2023. PMID: 37173311 Free PMC article.
14 results