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Page 1
Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.
Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, LeBlanc C, Burchfield E, Armand JR, Diaz-Gonzalez R, Ceballos-Perez G, García-Hernández R, Pérez-Moreno G, Bosch-Navarrete C, Ruiz-Pérez LM, Gamarro F, González-Pacanowska D, Navarro M, Mensa-Wilmot K, Pollastri MP, Kyle DE, Rice CA. Ferrins L, et al. Among authors: klug dm. Front Microbiol. 2023 May 10;14:1149145. doi: 10.3389/fmicb.2023.1149145. eCollection 2023. Front Microbiol. 2023. PMID: 37234530 Free PMC article.
Repurposing strategies for tropical disease drug discovery.
Klug DM, Gelb MH, Pollastri MP. Klug DM, et al. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2569-76. doi: 10.1016/j.bmcl.2016.03.103. Epub 2016 Mar 30. Bioorg Med Chem Lett. 2016. PMID: 27080183 Free PMC article. Review.
Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes MJ, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, Ferrins L. Bachovchin KA, et al. Among authors: klug dm. J Med Chem. 2019 Jan 24;62(2):665-687. doi: 10.1021/acs.jmedchem.8b01365. Epub 2019 Jan 10. J Med Chem. 2019. PMID: 30565932 Free PMC article.
Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.
Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Gomez-Pérez V, Ruiz-Pérez LM, Rojas-Barros DI, Gamarro F, González-Pacanowska D, Martínez-Martínez MS, Manzano P, Ferrins L, Caffrey CR, Navarro M, Pollastri MP. Klug DM, et al. PLoS Negl Trop Dis. 2019 Feb 8;13(2):e0007129. doi: 10.1371/journal.pntd.0007129. eCollection 2019 Feb. PLoS Negl Trop Dis. 2019. PMID: 30735501 Free PMC article.
Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics.
Klug DM, Tschiegg L, Diaz R, Rojas-Barros D, Perez-Moreno G, Ceballos G, García-Hernández R, Martinez-Martinez MS, Manzano P, Ruiz LM, Caffrey CR, Gamarro F, Pacanowska DG, Ferrins L, Navarro M, Pollastri MP. Klug DM, et al. J Med Chem. 2020 Mar 12;63(5):2527-2546. doi: 10.1021/acs.jmedchem.9b01506. Epub 2019 Nov 20. J Med Chem. 2020. PMID: 31670951 Free PMC article.
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. Singh B, et al. Among authors: klug dm. ACS Med Chem Lett. 2020 Jan 10;11(3):249-257. doi: 10.1021/acsmedchemlett.9b00453. eCollection 2020 Mar 12. ACS Med Chem Lett. 2020. PMID: 32184953 Free PMC article.
Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni.
Buskes MJ, Clements M, Bachovchin KA, Jalani HB, Leonard A, Bag S, Klug DM, Singh B, Campbell RF, Sciotti RJ, El-Sakkary N, Caffrey CR, Pollastri MP, Ferrins L. Buskes MJ, et al. Among authors: klug dm. ACS Med Chem Lett. 2020 Jan 10;11(3):258-265. doi: 10.1021/acsmedchemlett.9b00455. eCollection 2020 Mar 12. ACS Med Chem Lett. 2020. PMID: 32184954 Free PMC article.
Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity.
Klug DM, Diaz-Gonzalez R, DeLano TJ, Mavrogiannaki EM, Buskes MJ, Dalton RM, Fisher JK, Schneider KM, Hilborne V, Fritsche MG, Simpson QJ, Tear WF, Devine WG, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Bosch-Navarrete C, Ruiz-Pérez LM, Gamarro F, González-Pacanowska D, Martinez-Martinez MS, Manzano-Chinchon P, Navarro M, Pollastri MP, Ferrins L. Klug DM, et al. RSC Med Chem. 2020 Jul 10;11(8):950-959. doi: 10.1039/d0md00103a. eCollection 2020 Aug 1. RSC Med Chem. 2020. PMID: 33479690 Free PMC article.
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, Syed A, El-Sakkary N, Caffrey CR, Gamarro F, Ruiz-Perez LM, Gonzalez Pacanowska D, Ferrins L, Navarro M, Pollastri MP. Klug DM, et al. J Med Chem. 2021 Jul 8;64(13):9404-9430. doi: 10.1021/acs.jmedchem.1c00674. Epub 2021 Jun 22. J Med Chem. 2021. PMID: 34156862 Free PMC article.
Engaging the Medicinal Chemists of Tomorrow.
Ferrins L, Araujo E, Boudreau MW, Grenier-Davies MC, Haranahalli K, Journigan VB, Klug DM, Olson ME. Ferrins L, et al. Among authors: klug dm. J Med Chem. 2022 May 12;65(9):6353-6355. doi: 10.1021/acs.jmedchem.2c00424. Epub 2022 Apr 25. J Med Chem. 2022. PMID: 35467872
17 results