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Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data.
O'Donovan SD, Cavill R, Wimmenauer F, Lukas A, Stumm T, Smirnov E, Lenz M, Ertaylan G, Jennen DGJ, van Riel NAW, Driessens K, Peeters RLM, de Kok TMCM. O'Donovan SD, et al. Among authors: de kok tmcm. PLoS One. 2023 Nov 30;18(11):e0292030. doi: 10.1371/journal.pone.0292030. eCollection 2023. PLoS One. 2023. PMID: 38032940 Free PMC article.
Correction: Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256.
Bischoff NS, Proquin H, Jetten MJ, Schrooders Y, Jonkhout MCM, Briedé JJ, van Breda SG, Jennen DGJ, Medina-Reyes EI, Delgado-Buenrostro NL, Chirino YI, van Loveren H, de Kok TM. Bischoff NS, et al. Among authors: de kok tm. Nanomaterials (Basel). 2023 Oct 31;13(21):2888. doi: 10.3390/nano13212888. Nanomaterials (Basel). 2023. PMID: 37947754 Free PMC article.
A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.
Gall L, Jardi F, Lammens L, Piñero J, Souza TM, Rodrigues D, Jennen DGJ, de Kok TM, Coyle L, Chung SW, Ferreira S, Jo H, Beattie KA, Kelly C, Duckworth CA, Pritchard DM, Pin C. Gall L, et al. Among authors: de kok tm. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1511-1528. doi: 10.1002/psp4.13029. Epub 2023 Sep 11. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37621010 Free PMC article.
164 results