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mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, Tenkerian C, Morita M, Balanathan P, Jean-Jean O, Stambolic V, Trost M, Furic L, Larose L, Koromilas AE, Asano K, Litchfield D, Larsson O, Topisirovic I. Gandin V, et al. Among authors: koromilas ae. Nat Commun. 2016 Apr 4;7:11127. doi: 10.1038/ncomms11127. Nat Commun. 2016. PMID: 27040916 Free PMC article.
An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy.
Darini C, Ghaddar N, Chabot C, Assaker G, Sabri S, Wang S, Krishnamoorthy J, Buchanan M, Aguilar-Mahecha A, Abdulkarim B, Deschenes J, Torres J, Ursini-Siegel J, Basik M, Koromilas AE. Darini C, et al. Among authors: koromilas ae. Nat Commun. 2019 May 13;10(1):2139. doi: 10.1038/s41467-019-10138-8. Nat Commun. 2019. PMID: 31086176 Free PMC article.
Translational control of breast cancer plasticity.
Jewer M, Lee L, Leibovitch M, Zhang G, Liu J, Findlay SD, Vincent KM, Tandoc K, Dieters-Castator D, Quail DF, Dutta I, Coatham M, Xu Z, Puri A, Guan BJ, Hatzoglou M, Brumwell A, Uniacke J, Patsis C, Koromilas A, Schueler J, Siegers GM, Topisirovic I, Postovit LM. Jewer M, et al. Nat Commun. 2020 May 19;11(1):2498. doi: 10.1038/s41467-020-16352-z. Nat Commun. 2020. PMID: 32427827 Free PMC article.
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Ghaddar N, Wang S, Woodvine B, Krishnamoorthy J, van Hoef V, Darini C, Kazimierczak U, Ah-Son N, Popper H, Johnson M, Officer L, Teodósio A, Broggini M, Mann KK, Hatzoglou M, Topisirovic I, Larsson O, Le Quesne J, Koromilas AE. Ghaddar N, et al. Among authors: koromilas ae. Nat Commun. 2021 Jul 30;12(1):4651. doi: 10.1038/s41467-021-24661-0. Nat Commun. 2021. PMID: 34330898 Free PMC article.
A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer.
Cencic R, Im YK, Naineni SK, Moustafa-Kamal M, Jovanovic P, Sabourin V, Annis MG, Robert F, Schmeing TM, Koromilas A, Paquet M, Teodoro JG, Huang S, Siegel PM, Topisirovic I, Ursini-Siegel J, Pelletier J. Cencic R, et al. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2318093121. doi: 10.1073/pnas.2318093121. Epub 2024 Jan 17. Proc Natl Acad Sci U S A. 2024. PMID: 38232291 Free PMC article.
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase.
Wang S, Raven JF, Baltzis D, Kazemi S, Brunet DV, Hatzoglou M, Tremblay ML, Koromilas AE. Wang S, et al. Among authors: koromilas ae. J Biol Chem. 2006 Apr 7;281(14):9439-49. doi: 10.1074/jbc.M504977200. Epub 2006 Jan 23. J Biol Chem. 2006. PMID: 16431927 Free article.
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