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Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Tan AT, Linster M, Tan CW, Le Bert N, Chia WN, Kunasegaran K, Zhuang Y, Tham CYL, Chia A, Smith GJD, Young B, Kalimuddin S, Low JGH, Lye D, Wang LF, Bertoletti A. Tan AT, et al. Among authors: kunasegaran k. Cell Rep. 2021 Feb 9;34(6):108728. doi: 10.1016/j.celrep.2021.108728. Epub 2021 Jan 21. Cell Rep. 2021. PMID: 33516277 Free PMC article.
Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation.
Rivino L, Le Bert N, Gill US, Kunasegaran K, Cheng Y, Tan DZ, Becht E, Hansi NK, Foster GR, Su TH, Tseng TC, Lim SG, Kao JH, Newell EW, Kennedy PT, Bertoletti A. Rivino L, et al. Among authors: kunasegaran k. J Clin Invest. 2018 Feb 1;128(2):668-681. doi: 10.1172/JCI92812. Epub 2018 Jan 8. J Clin Invest. 2018. PMID: 29309050 Free PMC article.
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming.
Bénéchet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Fumagalli V, Lusito E, Moalli F, Bianchessi V, Andreata F, Zordan P, Bono E, Giustini L, Bonilla WV, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M. Bénéchet AP, et al. Among authors: kunasegaran k. Nature. 2019 Oct;574(7777):200-205. doi: 10.1038/s41586-019-1620-6. Epub 2019 Oct 2. Nature. 2019. PMID: 31582858 Free PMC article.
Effects of Hepatitis B Surface Antigen on Virus-Specific and Global T Cells in Patients With Chronic Hepatitis B Virus infection.
Le Bert N, Gill US, Hong M, Kunasegaran K, Tan DZM, Ahmad R, Cheng Y, Dutertre CA, Heinecke A, Rivino L, Tan A, Hansi NK, Zhang M, Xi S, Chong Y, Pflanz S, Newell EW, Kennedy PTF, Bertoletti A. Le Bert N, et al. Among authors: kunasegaran k. Gastroenterology. 2020 Aug;159(2):652-664. doi: 10.1053/j.gastro.2020.04.019. Epub 2020 Apr 14. Gastroenterology. 2020. PMID: 32302614
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Le Bert N, Tan AT, Kunasegaran K, Tham CYL, Hafezi M, Chia A, Chng MHY, Lin M, Tan N, Linster M, Chia WN, Chen MI, Wang LF, Ooi EE, Kalimuddin S, Tambyah PA, Low JG, Tan YJ, Bertoletti A. Le Bert N, et al. Among authors: kunasegaran k. Nature. 2020 Aug;584(7821):457-462. doi: 10.1038/s41586-020-2550-z. Epub 2020 Jul 15. Nature. 2020. PMID: 32668444
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.
Le Bert N, Clapham HE, Tan AT, Chia WN, Tham CYL, Lim JM, Kunasegaran K, Tan LWL, Dutertre CA, Shankar N, Lim JME, Sun LJ, Zahari M, Tun ZM, Kumar V, Lim BL, Lim SH, Chia A, Tan YJ, Tambyah PA, Kalimuddin S, Lye D, Low JGH, Wang LF, Wan WY, Hsu LY, Bertoletti A, Tam CC. Le Bert N, et al. Among authors: kunasegaran k. J Exp Med. 2021 May 3;218(5):e20202617. doi: 10.1084/jem.20202617. J Exp Med. 2021. PMID: 33646265 Free PMC article. Clinical Trial.
Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.
Chia WN, Zhu F, Ong SWX, Young BE, Fong SW, Le Bert N, Tan CW, Tiu C, Zhang J, Tan SY, Pada S, Chan YH, Tham CYL, Kunasegaran K, Chen MI, Low JGH, Leo YS, Renia L, Bertoletti A, Ng LFP, Lye DC, Wang LF. Chia WN, et al. Among authors: kunasegaran k. Lancet Microbe. 2021 Jun;2(6):e240-e249. doi: 10.1016/S2666-5247(21)00025-2. Epub 2021 Mar 23. Lancet Microbe. 2021. PMID: 33778792 Free PMC article.
Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men.
Le Bert N, Chia WN, Wan WY, Teo AKJ, Chong SZ, Tan N, Tan DSC, Chia A, Tan IB, Kunasegaran K, Chua QX, Abdad MY, Ng ASH, Vasoo S, Ang JX, Lee MS, Sun L, Fang J, Zhu F, Cook AR, Aw TC, Huang J, Tam C, Lee FS, Clapham H, Goh EJ, Peou MSS, Tan SP, Ong SK, Wang LF, Bertoletti A, Hsu LY, Ong BC. Le Bert N, et al. Among authors: kunasegaran k. Emerg Microbes Infect. 2021 Dec;10(1):2141-2150. doi: 10.1080/22221751.2021.1999777. Emerg Microbes Infect. 2021. PMID: 34709140 Free PMC article.
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