Kwong AD - Search Results

1

Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir.

Sarrazin C, Kieffer TL, Bartels D, Hanzelka B, Müh U, Welker M, Wincheringer D, Zhou Y, Chu HM, Lin C, Weegink C, Reesink H, Zeuzem S, Kwong AD. Sarrazin C, et al. Among authors: kwong ad. Gastroenterology. 2007 May;132(5):1767-77. doi: 10.1053/j.gastro.2007.02.037. Epub 2007 Feb 21. Gastroenterology. 2007. PMID: 17484874 Clinical Trial.

2

HVR-1 heterogeneity during treatment with telaprevir with or without pegylated interferon alfa-2a.

Lange CM, Susser S, Herrmann E, Karey U, Kieffer TL, Kwong AD, Schinkel J, Reesink HW, Zeuzem S, Sarrazin C. Lange CM, et al. Among authors: kwong ad. Scand J Gastroenterol. 2011 Nov;46(11):1362-8. doi: 10.3109/00365521.2011.605465. Epub 2011 Aug 5. Scand J Gastroenterol. 2011. PMID: 21815864 Clinical Trial.

3

Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells.

Lin K, Kwong AD, Lin C. Lin K, et al. Among authors: kwong ad. Antimicrob Agents Chemother. 2004 Dec;48(12):4784-92. doi: 10.1128/AAC.48.12.4784-4792.2004. Antimicrob Agents Chemother. 2004. PMID: 15561857 Free PMC article.

4

Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.

Zhou Y, Müh U, Hanzelka BL, Bartels DJ, Wei Y, Rao BG, Brennan DL, Tigges AM, Swenson L, Kwong AD, Lin C. Zhou Y, et al. Among authors: kwong ad. J Biol Chem. 2007 Aug 3;282(31):22619-28. doi: 10.1074/jbc.M610207200. Epub 2007 Jun 6. J Biol Chem. 2007. PMID: 17556358 Free article.

5

Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients.

Kieffer TL, Sarrazin C, Miller JS, Welker MW, Forestier N, Reesink HW, Kwong AD, Zeuzem S. Kieffer TL, et al. Among authors: kwong ad. Hepatology. 2007 Sep;46(3):631-9. doi: 10.1002/hep.21781. Hepatology. 2007. PMID: 17680654 Clinical Trial.

6

Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease.

Zhou Y, Bartels DJ, Hanzelka BL, Müh U, Wei Y, Chu HM, Tigges AM, Brennan DL, Rao BG, Swenson L, Kwong AD, Lin C. Zhou Y, et al. Among authors: kwong ad. Antimicrob Agents Chemother. 2008 Jan;52(1):110-20. doi: 10.1128/AAC.00863-07. Epub 2007 Oct 15. Antimicrob Agents Chemother. 2008. PMID: 17938182 Free PMC article. Clinical Trial.

7

Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects.

Bartels DJ, Zhou Y, Zhang EZ, Marcial M, Byrn RA, Pfeiffer T, Tigges AM, Adiwijaya BS, Lin C, Kwong AD, Kieffer TL. Bartels DJ, et al. Among authors: kwong ad. J Infect Dis. 2008 Sep 15;198(6):800-7. doi: 10.1086/591141. J Infect Dis. 2008. PMID: 18637752

8

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.

Adiwijaya BS, Herrmann E, Hare B, Kieffer T, Lin C, Kwong AD, Garg V, Randle JC, Sarrazin C, Zeuzem S, Caron PR. Adiwijaya BS, et al. Among authors: kwong ad. PLoS Comput Biol. 2010 Apr 15;6(4):e1000745. doi: 10.1371/journal.pcbi.1000745. PLoS Comput Biol. 2010. PMID: 20419154 Free PMC article.

9

Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment.

Sullivan JC, Zhang EZ, Bartels DJ, Tigges A, Dorrian JL, Kwong AD, Kieffer TL. Sullivan JC, et al. Among authors: kwong ad. Virol J. 2012 Aug 6;9:147. doi: 10.1186/1743-422X-9-147. Virol J. 2012. PMID: 22866919 Free PMC article.

10

Characterization of V36C, a novel amino acid substitution conferring hepatitis C virus (HCV) resistance to telaprevir, a potent peptidomimetic inhibitor of HCV protease.

Barbotte L, Ahmed-Belkacem A, Chevaliez S, Soulier A, Hézode C, Wajcman H, Bartels DJ, Zhou Y, Ardzinski A, Mani N, Rao BG, George S, Kwong A, Pawlotsky JM. Barbotte L, et al. Antimicrob Agents Chemother. 2010 Jun;54(6):2681-3. doi: 10.1128/AAC.01796-09. Epub 2010 Apr 5. Antimicrob Agents Chemother. 2010. PMID: 20368394 Free PMC article.

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