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Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates.
Monath TP, Soike K, Levenbook I, Zhang ZX, Arroyo J, Delagrave S, Myers G, Barrett AD, Shope RE, Ratterree M, Chambers TJ, Guirakhoo F. Monath TP, et al. Among authors: levenbook i. Vaccine. 1999 Apr 9;17(15-16):1869-82. doi: 10.1016/s0264-410x(98)00487-3. Vaccine. 1999. PMID: 10217584
A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.
Guirakhoo F, Zhang Z, Myers G, Johnson BW, Pugachev K, Nichols R, Brown N, Levenbook I, Draper K, Cyrek S, Lang J, Fournier C, Barrere B, Delagrave S, Monath TP. Guirakhoo F, et al. Among authors: levenbook i. J Virol. 2004 Sep;78(18):9998-10008. doi: 10.1128/JVI.78.18.9998-10008.2004. J Virol. 2004. PMID: 15331733 Free PMC article.
Safety testing for neurovirulence of novel live, attenuated flavivirus vaccines: infant mice provide an accurate surrogate for the test in monkeys.
Monath TP, Myers GA, Beck RA, Knauber M, Scappaticci K, Pullano T, Archambault WT, Catalan J, Miller C, Zhang ZX, Shin S, Pugachev K, Draper K, Levenbook IS, Guirakhoo F. Monath TP, et al. Among authors: levenbook is. Biologicals. 2005 Sep;33(3):131-44. doi: 10.1016/j.biologicals.2005.03.009. Biologicals. 2005. PMID: 15975826
Single mutation in the flavivirus envelope protein hinge region increases neurovirulence for mice and monkeys but decreases viscerotropism for monkeys: relevance to development and safety testing of live, attenuated vaccines.
Monath TP, Arroyo J, Levenbook I, Zhang ZX, Catalan J, Draper K, Guirakhoo F. Monath TP, et al. Among authors: levenbook i. J Virol. 2002 Feb;76(4):1932-43. doi: 10.1128/jvi.76.4.1932-1943.2002. J Virol. 2002. PMID: 11799188 Free PMC article.
Safety and efficacy of chimeric yellow Fever-dengue virus tetravalent vaccine formulations in nonhuman primates.
Guirakhoo F, Pugachev K, Zhang Z, Myers G, Levenbook I, Draper K, Lang J, Ocran S, Mitchell F, Parsons M, Brown N, Brandler S, Fournier C, Barrere B, Rizvi F, Travassos A, Nichols R, Trent D, Monath T. Guirakhoo F, et al. Among authors: levenbook i. J Virol. 2004 May;78(9):4761-75. doi: 10.1128/jvi.78.9.4761-4775.2004. J Virol. 2004. PMID: 15078958 Free PMC article.
53 results