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Signaling networks in immunometabolism.
Saravia J, Raynor JL, Chapman NM, Lim SA, Chi H. Saravia J, et al. Among authors: lim sa. Cell Res. 2020 Apr;30(4):328-342. doi: 10.1038/s41422-020-0301-1. Epub 2020 Mar 20. Cell Res. 2020. PMID: 32203134 Free PMC article. Review.
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.
Karmaus PWF, Chen X, Lim SA, Herrada AA, Nguyen TM, Xu B, Dhungana Y, Rankin S, Chen W, Rosencrance C, Yang K, Fan Y, Cheng Y, Easton J, Neale G, Vogel P, Chi H. Karmaus PWF, et al. Among authors: lim sa. Nature. 2019 Jan;565(7737):101-105. doi: 10.1038/s41586-018-0806-7. Epub 2018 Dec 19. Nature. 2019. PMID: 30568299 Free PMC article.
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.
Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. Wei J, et al. Among authors: lim sa. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11. Nature. 2019. PMID: 31827283 Free PMC article.
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity.
Long L, Wei J, Lim SA, Raynor JL, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NM, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang YD, Li Y, Niu M, Dhungana Y, Kc A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H. Long L, et al. Among authors: lim sa. Nature. 2021 Dec;600(7888):308-313. doi: 10.1038/s41586-021-04109-7. Epub 2021 Nov 18. Nature. 2021. PMID: 34795452 Free PMC article.
Lipid metabolism in T cell signaling and function.
Lim SA, Su W, Chapman NM, Chi H. Lim SA, et al. Nat Chem Biol. 2022 May;18(5):470-481. doi: 10.1038/s41589-022-01017-3. Epub 2022 Apr 28. Nat Chem Biol. 2022. PMID: 35484263 Review.
PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis.
Blanco DB, Chapman NM, Raynor JL, Xu C, Su W, Kc A, Li W, Lim SA, Schattgen S, Shi H, Risch I, Sun Y, Dhungana Y, Kim Y, Wei J, Rankin S, Neale G, Thomas PG, Yang K, Chi H. Blanco DB, et al. Among authors: lim sa. Nat Cell Biol. 2022 Nov;24(11):1642-1654. doi: 10.1038/s41556-022-01011-w. Epub 2022 Oct 27. Nat Cell Biol. 2022. PMID: 36302969 Free PMC article.
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity.
Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, Sun X, Saravia J, Rankin S, Dhungana Y, Chi H. Guo C, et al. Among authors: lim sa. Nature. 2023 Aug;620(7972):200-208. doi: 10.1038/s41586-023-06299-8. Epub 2023 Jul 5. Nature. 2023. PMID: 37407815 Free PMC article.
CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer's disease pathology.
Su W, Saravia J, Risch I, Rankin S, Guy C, Chapman NM, Shi H, Sun Y, Kc A, Li W, Huang H, Lim SA, Hu H, Wang Y, Liu D, Jiao Y, Chen PC, Soliman H, Yan KK, Zhang J, Vogel P, Liu X, Serrano GE, Beach TG, Yu J, Peng J, Chi H. Su W, et al. Among authors: lim sa. Nat Immunol. 2023 Oct;24(10):1735-1747. doi: 10.1038/s41590-023-01604-z. Epub 2023 Sep 7. Nat Immunol. 2023. PMID: 37679549
Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer.
Zhou P, Shi H, Huang H, Sun X, Yuan S, Chapman NM, Connelly JP, Lim SA, Saravia J, Kc A, Pruett-Miller SM, Chi H. Zhou P, et al. Among authors: lim sa. Nature. 2023 Dec;624(7990):154-163. doi: 10.1038/s41586-023-06733-x. Epub 2023 Nov 15. Nature. 2023. PMID: 37968405 Free PMC article.
160 results