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The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange.
Biochemistry. 2002 Oct 15;41(41):12336-42. doi: 10.1021/bi0259103.
Biochemistry. 2002.
PMID: 12369822
Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum.
Jacob P, Rossmann H, Lamprecht G, Kretz A, Neff C, Lin-Wu E, Gregor M, Groneberg DA, Kere J, Seidler U.
Jacob P, et al. Among authors: lin wu e.
Gastroenterology. 2002 Mar;122(3):709-24. doi: 10.1053/gast.2002.31875.
Gastroenterology. 2002.
PMID: 11875004
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