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Potently neutralizing and protective human antibodies against SARS-CoV-2.
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr. Zost SJ, et al. Among authors: loo ym. Nature. 2020 Aug;584(7821):443-449. doi: 10.1038/s41586-020-2548-6. Epub 2020 Jul 15. Nature. 2020. PMID: 32668443 Free PMC article.
Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals.
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, Martinez DR, Schäfer A, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE. Zost SJ, et al. Among authors: loo ym. bioRxiv [Preprint]. 2020 May 22:2020.05.22.111005. doi: 10.1101/2020.05.22.111005. bioRxiv. 2020. PMID: 32511409 Free PMC article. Updated. Preprint.
Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail.
Dong J, Zost S, Greaney A, Starr TN, Dingens AS, Chen EC, Chen R, Case B, Sutton R, Gilchuk P, Rodriguez J, Armstrong E, Gainza C, Nargi R, Binshtein E, Xie X, Zhang X, Shi PY, Logue J, Weston S, McGrath M, Frieman M, Brady T, Tuffy K, Bright H, Loo YM, McvTamney P, Esser M, Carnahan R, Diamond M, Bloom J, Crowe JE. Dong J, et al. Among authors: loo ym. bioRxiv [Preprint]. 2021 Mar 1:2021.01.27.428529. doi: 10.1101/2021.01.27.428529. bioRxiv. 2021. PMID: 33532768 Free PMC article. Updated. Preprint.
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.
Dong J, Zost SJ, Greaney AJ, Starr TN, Dingens AS, Chen EC, Chen RE, Case JB, Sutton RE, Gilchuk P, Rodriguez J, Armstrong E, Gainza C, Nargi RS, Binshtein E, Xie X, Zhang X, Shi PY, Logue J, Weston S, McGrath ME, Frieman MB, Brady T, Tuffy KM, Bright H, Loo YM, McTamney PM, Esser MT, Carnahan RH, Diamond MS, Bloom JD, Crowe JE Jr. Dong J, et al. Among authors: loo ym. Nat Microbiol. 2021 Oct;6(10):1233-1244. doi: 10.1038/s41564-021-00972-2. Epub 2021 Sep 21. Nat Microbiol. 2021. PMID: 34548634 Free PMC article.
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans.
Loo YM, McTamney PM, Arends RH, Abram ME, Aksyuk AA, Diallo S, Flores DJ, Kelly EJ, Ren K, Roque R, Rosenthal K, Streicher K, Tuffy KM, Bond NJ, Cornwell O, Bouquet J, Cheng LI, Dunyak J, Huang Y, Rosenbaum AI, Pilla Reddy V, Andersen H, Carnahan RH, Crowe JE Jr, Kuehne AI, Herbert AS, Dye JM, Bright H, Kallewaard NL, Pangalos MN, Esser MT. Loo YM, et al. Sci Transl Med. 2022 Mar 9;14(635):eabl8124. doi: 10.1126/scitranslmed.abl8124. Epub 2022 Mar 9. Sci Transl Med. 2022. PMID: 35076282 Free PMC article.
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains.
Case JB, Mackin S, Errico JM, Chong Z, Madden EA, Whitener B, Guarino B, Schmid MA, Rosenthal K, Ren K, Dang HV, Snell G, Jung A, Droit L, Handley SA, Halfmann PJ, Kawaoka Y, Crowe JE Jr, Fremont DH, Virgin HW, Loo YM, Esser MT, Purcell LA, Corti D, Diamond MS. Case JB, et al. Among authors: loo ym. Nat Commun. 2022 Jul 2;13(1):3824. doi: 10.1038/s41467-022-31615-7. Nat Commun. 2022. PMID: 35780162 Free PMC article.
A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques.
Nkolola JP, Yu J, Wan H, Chang A, McMahan K, Anioke T, Jacob-Dolan C, Powers O, Ye T, Chandrashekar A, Sellers D, Barrett J, Loo YM, Esser MT, Carnahan RH, Crowe JE Jr, Barouch DH. Nkolola JP, et al. Among authors: loo ym. Sci Transl Med. 2022 Oct 5;14(665):eabo6160. doi: 10.1126/scitranslmed.abo6160. Epub 2022 Oct 5. Sci Transl Med. 2022. PMID: 35857623 Free PMC article.
Unveiling viral enablers.
Loo YM, Gale M Jr. Loo YM, et al. Nat Biotechnol. 2008 Oct;26(10):1093-4. doi: 10.1038/nbt1008-1093. Nat Biotechnol. 2008. PMID: 18846077 No abstract available.
54 results