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Cellular and molecular mechanisms of action of bisphosphonates.
Rogers MJ, Gordon S, Benford HL, Coxon FP, Luckman SP, Monkkonen J, Frith JC. Rogers MJ, et al. Among authors: luckman sp. Cancer. 2000 Jun 15;88(12 Suppl):2961-78. doi: 10.1002/1097-0142(20000615)88:12+<2961::aid-cncr12>3.3.co;2-c. Cancer. 2000. PMID: 10898340 Review.
Molecular mechanisms of action of bisphosphonates.
Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Mönkkönen J, Auriola S, Chilton KM, Russell RG. Rogers MJ, et al. Among authors: luckman sp. Bone. 1999 May;24(5 Suppl):73S-79S. doi: 10.1016/s8756-3282(99)00070-8. Bone. 1999. PMID: 10321934 Review. No abstract available.
JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).
Luckman SP, Hughes DE, Coxon FP, Russell GG, Rogers MJ. Luckman SP, et al. J Bone Miner Res. 2005 Jul;20(7):1265-74. doi: 10.1359/jbmr.2005.20.7.1265. J Bone Miner Res. 2005. PMID: 16050006 Free article. No abstract available.
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA. Fisher JE, et al. Among authors: luckman sp. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. doi: 10.1073/pnas.96.1.133. Proc Natl Acad Sci U S A. 1999. PMID: 9874784 Free PMC article.
Matrix metalloproteinases in myasthenia gravis.
Helgeland G, Petzold A, Luckman SP, Gilhus NE, Plant GT, Romi FR. Helgeland G, et al. Among authors: luckman sp. Eur Neurol. 2011;65(1):53-8. doi: 10.1159/000322737. Epub 2011 Jan 6. Eur Neurol. 2011. PMID: 21212676
15 results