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Showing results for mucklewells b
Search for Mackenwells B instead (1 results)
Biologic agents in the treatment of urticaria.
Kaplan AP. Kaplan AP. Curr Allergy Asthma Rep. 2012 Aug;12(4):288-91. doi: 10.1007/s11882-012-0268-1. Curr Allergy Asthma Rep. 2012. PMID: 22740008 Review.
Other agents require further evaluation for possible efficacy in the treatment of chronic spontaneous urticaria, including antibody to CD20, a B-lymphocyte cell surface marker, anti-TNFalpha, and anti-Interleukin 1. ...
Other agents require further evaluation for possible efficacy in the treatment of chronic spontaneous urticaria, including antibody to CD20, …
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. Ambrus-Aikelin G, et al. Sci Rep. 2023 Aug 19;13(1):13524. doi: 10.1038/s41598-023-39805-z. Sci Rep. 2023. PMID: 37598239 Free PMC article.
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
Povero D, Lazic M, McBride C, Ambrus-Aikelin G, Stansfield R, Johnson CD, Santini AM, Pranadinata RF, McGeough MD, Stafford JA, Hoffman HM, Feldstein AE, Veal JM, Bain G. Povero D, et al. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258. doi: 10.1124/jpet.123.001639. Epub 2023 Jun 12. J Pharmacol Exp Ther. 2023. PMID: 37308266
We describe in this study the preclinical pharmacologic, pharmacokinetic, and pharmacodynamic properties of a novel and highly specific NLRP3 inhibitor, JT001 (6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonylurea). In cell-based assays, JT001 potently and selectively …
We describe in this study the preclinical pharmacologic, pharmacokinetic, and pharmacodynamic properties of a novel and highly specific NLRP …
[Hereditary systemic autoinflammatory diseases. Part II: cryopyrin-associated periodic syndromes, pediatric systemic granulomatosis and PAPA syndrome].
Aróstegui JI, Yagüe J. Aróstegui JI, et al. Med Clin (Barc). 2008 Mar 29;130(11):429-38. doi: 10.1157/13117854. Med Clin (Barc). 2008. PMID: 18394369 Review. Spanish.
The present review is the second and last part of an updated and comprehensive overview of hereditary systemic autoinflammatory diseases, and will introduce persistent, non-periodic autoinflammatory diseases, such as: a) the group of cryopyrin-associated periodic syndromes (CAPS) …
The present review is the second and last part of an updated and comprehensive overview of hereditary systemic autoinflammatory diseases, an …
Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update.
Breda L, Nozzi M, De Sanctis S, Chiarelli F. Breda L, et al. Semin Arthritis Rheum. 2010 Aug;40(1):53-72. doi: 10.1016/j.semarthrit.2008.12.001. Epub 2009 Feb 26. Semin Arthritis Rheum. 2010. PMID: 19246077 Review.
ASO titer should be obtained to confirm a diagnosis of acute rheumatic fever; other important antibody markers of streptococcal infection include antihyaluronidase, antideoxyribonuclease B, and antistreptokinase antibodies. We also found that, in the pediatric age, the mai …
ASO titer should be obtained to confirm a diagnosis of acute rheumatic fever; other important antibody markers of streptococcal infection in …
Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.
Fujisawa A, Kambe N, Saito M, Nishikomori R, Tanizaki H, Kanazawa N, Adachi S, Heike T, Sagara J, Suda T, Nakahata T, Miyachi Y. Fujisawa A, et al. Blood. 2007 Apr 1;109(7):2903-11. doi: 10.1182/blood-2006-07-033597. Blood. 2007. PMID: 17164343 Free article.
The features of cell death, including 7-AAD staining, the presence of cellular edema, and early membrane damage resulting in lactate dehydrogenase (LDH) release, indicated that it was more likely to be necrosis than apoptosis, and was effectively blocked with the cathepsin B …
The features of cell death, including 7-AAD staining, the presence of cellular edema, and early membrane damage resulting in lactate dehydro …
23 results