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53 results

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Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function.
Liu CC, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, Doss SV, Shue F, Jeevaratnam S, Bastea L, Wang N, Martens YA, Qiao W, Wang M, Zhao N, Jia L, Yamazaki Y, Yamazaki A, Rosenberg CL, Wang Z, Kong D, Li Z, Kuchenbecker LA, Trottier ZA, Felton L, Rogers J, Quicksall ZS, Linares C, Knight J, Chen Y, Kurti A, Kanekiyo T, Fryer JD, Asmann YW, Storz P, Wang X, Peng J, Zhang B, Kim BYS, Bu G. Liu CC, et al. Among authors: martens ya. Nat Neurosci. 2022 Aug;25(8):1020-1033. doi: 10.1038/s41593-022-01127-0. Epub 2022 Aug 1. Nat Neurosci. 2022. PMID: 35915180 Free PMC article.
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia.
Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens YA, Wang X, Li L, Liu CC, Chen K, Zhu Y, Ikezu TC, Li Z, Meneses AD, Jin Y, Knight JA, Chen Y, Bastea L, Linares C, Sonustun B, Job L, Smith ML, Xie M, Liu YU, Umpierre AD, Haruwaka K, Quicksall ZS, Storz P, Asmann YW, Wu LJ, Bu G. Zhao N, et al. Among authors: martens ya. J Exp Med. 2022 Dec 5;219(12):e20212479. doi: 10.1084/jem.20212479. Epub 2022 Sep 15. J Exp Med. 2022. PMID: 36107206 Free PMC article.
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease.
Liu CC, Wang N, Chen Y, Inoue Y, Shue F, Ren Y, Wang M, Qiao W, Ikezu TC, Li Z, Zhao J, Martens Y, Doss SV, Rosenberg CL, Jeevaratnam S, Jia L, Raulin AC, Qi F, Zhu Y, Alnobani A, Knight J, Chen Y, Linares C, Kurti A, Fryer JD, Zhang B, Wu LJ, Kim BYS, Bu G. Liu CC, et al. Among authors: martens y. Nat Immunol. 2023 Nov;24(11):1854-1866. doi: 10.1038/s41590-023-01640-9. Epub 2023 Oct 19. Nat Immunol. 2023. PMID: 37857825
LRP1 is a neuronal receptor for α-synuclein uptake and spread.
Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J, Chen Y, Jin Y, Linares C, Goodwin M, Li Y, Liu CC, Kanekiyo T, Holtzman DM, Golde TE, Bu G, Zhao N. Chen K, et al. Among authors: martens ya. Mol Neurodegener. 2022 Sep 2;17(1):57. doi: 10.1186/s13024-022-00560-w. Mol Neurodegener. 2022. PMID: 36056345 Free PMC article.
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. Zhao J, et al. Among authors: martens ya. Nat Commun. 2020 Nov 2;11(1):5540. doi: 10.1038/s41467-020-19264-0. Nat Commun. 2020. PMID: 33139712 Free PMC article.
Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, Bastea L, Meneses AD, Chen K, Thompson JW, St John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G. Zhao N, et al. Among authors: martens ya. Neuron. 2020 Jun 3;106(5):727-742.e6. doi: 10.1016/j.neuron.2020.02.034. Epub 2020 Mar 20. Neuron. 2020. PMID: 32199103 Free PMC article.
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism.
Kawatani K, Holm ML, Starling SC, Martens YA, Zhao J, Lu W, Ren Y, Li Z, Jiang P, Jiang Y, Baker SK, Wang N, Roy B, Parsons TM, Perkerson RB 3rd, Bao H, Han X, Bu G, Kanekiyo T. Kawatani K, et al. Among authors: martens ya. Mol Psychiatry. 2023 Dec 22. doi: 10.1038/s41380-023-02372-w. Online ahead of print. Mol Psychiatry. 2023. PMID: 38135757
53 results