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CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.
Jähnichen S, Blanchetot C, Maussang D, Gonzalez-Pajuelo M, Chow KY, Bosch L, De Vrieze S, Serruys B, Ulrichts H, Vandevelde W, Saunders M, De Haard HJ, Schols D, Leurs R, Vanlandschoot P, Verrips T, Smit MJ. Jähnichen S, et al. Among authors: maussang d. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20565-70. doi: 10.1073/pnas.1012865107. Epub 2010 Nov 8. Proc Natl Acad Sci U S A. 2010. PMID: 21059953 Free PMC article.
Pharmacological modulation of chemokine receptor function.
Scholten DJ, Canals M, Maussang D, Roumen L, Smit MJ, Wijtmans M, de Graaf C, Vischer HF, Leurs R. Scholten DJ, et al. Among authors: maussang d. Br J Pharmacol. 2012 Mar;165(6):1617-1643. doi: 10.1111/j.1476-5381.2011.01551.x. Br J Pharmacol. 2012. PMID: 21699506 Free PMC article. Review.
Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.
Maussang D, Mujić-Delić A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen GA, Merchiers P, van Rompaey P, Smit MJ. Maussang D, et al. J Biol Chem. 2013 Oct 11;288(41):29562-72. doi: 10.1074/jbc.M113.498436. Epub 2013 Aug 26. J Biol Chem. 2013. PMID: 23979133 Free PMC article.
CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome.
de Wit RH, Heukers R, Brink HJ, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer HF, Bachelerie F, Smit MJ. de Wit RH, et al. Among authors: maussang d. J Pharmacol Exp Ther. 2017 Oct;363(1):35-44. doi: 10.1124/jpet.117.242735. Epub 2017 Aug 2. J Pharmacol Exp Ther. 2017. PMID: 28768817
The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.
van Senten JR, Bebelman MP, Fan TS, Heukers R, Bergkamp ND, van Gasselt P, Langemeijer EV, Slinger E, Lagerweij T, Rahbar A, Stigter-van Walsum M, Maussang D, Leurs R, Musters RJP, van Dongen GAMS, Söderberg-Nauclér C, Würdinger T, Siderius M, Smit MJ. van Senten JR, et al. Among authors: maussang d. J Biol Chem. 2019 Nov 1;294(44):16297-16308. doi: 10.1074/jbc.RA119.007796. Epub 2019 Sep 13. J Biol Chem. 2019. PMID: 31519750 Free PMC article.
22 results