Medema JP - Search Results

1

Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin.

Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, de Esch IJ, Richel D, Wijtmans M. Hulsman N, et al. Among authors: medema jp. J Med Chem. 2007 May 17;50(10):2424-31. doi: 10.1021/jm061371e. Epub 2007 Apr 19. J Med Chem. 2007. PMID: 17441704

2

The developing cancer stem-cell model: clinical challenges and opportunities.

Vermeulen L, de Sousa e Melo F, Richel DJ, Medema JP. Vermeulen L, et al. Among authors: medema jp. Lancet Oncol. 2012 Feb;13(2):e83-9. doi: 10.1016/S1470-2045(11)70257-1. Lancet Oncol. 2012. PMID: 22300863 Review.

3

Targeting Wnt signaling in colon cancer stem cells.

de Sousa EM, Vermeulen L, Richel D, Medema JP. de Sousa EM, et al. Among authors: medema jp. Clin Cancer Res. 2011 Feb 15;17(4):647-53. doi: 10.1158/1078-0432.CCR-10-1204. Epub 2010 Dec 15. Clin Cancer Res. 2011. PMID: 21159886 Review.

4

[Cancer stem cells].

Vermeulen L, Verhoeff JJ, Richel DJ, Medema JP. Vermeulen L, et al. Among authors: medema jp. Ned Tijdschr Geneeskd. 2009 Feb 14;153(7):286-90. Ned Tijdschr Geneeskd. 2009. PMID: 19291944 Review. Dutch. No abstract available.

5

Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis.

de Jong JH, Rodermond HM, Zimberlin CD, Lascano V, De Sousa E Melo F, Richel DJ, Medema JP, Vermeulen L. de Jong JH, et al. Among authors: medema jp. Sci Rep. 2012;2:271. doi: 10.1038/srep00271. Epub 2012 Feb 15. Sci Rep. 2012. PMID: 22355783 Free PMC article.

6

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

Vermeulen L, Todaro M, de Sousa Mello F, Sprick MR, Kemper K, Perez Alea M, Richel DJ, Stassi G, Medema JP. Vermeulen L, et al. Among authors: medema jp. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13427-32. doi: 10.1073/pnas.0805706105. Epub 2008 Sep 2. Proc Natl Acad Sci U S A. 2008. PMID: 18765800 Free PMC article.

7

Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.

de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP. de Sousa E Melo F, et al. Among authors: medema jp. Cell Stem Cell. 2011 Nov 4;9(5):476-85. doi: 10.1016/j.stem.2011.10.008. Cell Stem Cell. 2011. PMID: 22056143 Free article.

8

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP. Vermeulen L, et al. Among authors: medema jp. Nat Cell Biol. 2010 May;12(5):468-76. doi: 10.1038/ncb2048. Epub 2010 Apr 25. Nat Cell Biol. 2010. PMID: 20418870

9

Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.

Kessler JH, Mullauer FB, de Roo GM, Medema JP. Kessler JH, et al. Among authors: medema jp. Cancer Lett. 2007 Jun 18;251(1):132-45. doi: 10.1016/j.canlet.2006.11.003. Epub 2006 Dec 13. Cancer Lett. 2007. PMID: 17169485

10

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion.

Mullauer FB, Kessler JH, Medema JP. Mullauer FB, et al. Among authors: medema jp. Apoptosis. 2009 Feb;14(2):191-202. doi: 10.1007/s10495-008-0290-x. Apoptosis. 2009. PMID: 19115109

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