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TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients.
Zom GG, Welters MJ, Loof NM, Goedemans R, Lougheed S, Valentijn RR, Zandvliet ML, Meeuwenoord NJ, Melief CJ, de Gruijl TD, Van der Marel GA, Filippov DV, Ossendorp F, Van der Burg SH. Zom GG, et al. Among authors: meeuwenoord nj. Oncotarget. 2016 Oct 11;7(41):67087-67100. doi: 10.18632/oncotarget.11512. Oncotarget. 2016. PMID: 27564262 Free PMC article.
Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions.
Speetjens FM, Welters MJP, Slingerland M, van Poelgeest MIE, de Vos van Steenwijk PJ, Roozen I, Boekestijn S, Loof NM, Zom GG, Valentijn ARPM, Krebber WJ, Meeuwenoord NJ, Janssen CAH, Melief CJM, van der Marel GA, Filippov DV, van der Burg SH, Gelderblom H, Ossendorp F. Speetjens FM, et al. Among authors: meeuwenoord nj. J Immunother Cancer. 2022 Oct;10(10):e005016. doi: 10.1136/jitc-2022-005016. J Immunother Cancer. 2022. PMID: 36261215 Free PMC article. Clinical Trial.
N-tetradecylcarbamyl lipopeptides as novel agonists for Toll-like receptor 2.
Willems MM, Zom GG, Khan S, Meeuwenoord N, Melief CJ, van der Stelt M, Overkleeft HS, Codée JD, van der Marel GA, Ossendorp F, Filippov DV. Willems MM, et al. J Med Chem. 2014 Aug 14;57(15):6873-8. doi: 10.1021/jm500722p. Epub 2014 Jul 23. J Med Chem. 2014. PMID: 25019313
Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates.
Gential GP, Ho NI, Chiodo F, Meeuwenoord N, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV. Gential GP, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3641-5. doi: 10.1016/j.bmcl.2016.05.094. Epub 2016 Jun 1. Bioorg Med Chem Lett. 2016. PMID: 27289322
Simplified Monopalmitoyl Toll-like Receptor 2 Ligand Mini-UPam for Self-Adjuvanting Neoantigen-Based Synthetic Cancer Vaccines.
van den Ende TC, Heuts JMM, Gential GPP, Visser M, van de Graaff MJ, Ho NI, Jiskoot W, Valentijn ARPM, Meeuwenoord NJ, Overkleeft HS, Codée JDC, van der Burg SH, Verdegaal EME, van der Marel GA, Ossendorp F, Filippov DV. van den Ende TC, et al. Among authors: meeuwenoord nj. Chembiochem. 2021 Apr 6;22(7):1215-1222. doi: 10.1002/cbic.202000687. Epub 2020 Dec 22. Chembiochem. 2021. PMID: 33180981 Free PMC article.
53 results