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Delivering safer immunotherapies for cancer.
Milling L, Zhang Y, Irvine DJ. Milling L, et al. Adv Drug Deliv Rev. 2017 May 15;114:79-101. doi: 10.1016/j.addr.2017.05.011. Epub 2017 May 22. Adv Drug Deliv Rev. 2017. PMID: 28545888 Free PMC article. Review.
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity.
Dane EL, Belessiotis-Richards A, Backlund C, Wang J, Hidaka K, Milling LE, Bhagchandani S, Melo MB, Wu S, Li N, Donahue N, Ni K, Ma L, Okaniwa M, Stevens MM, Alexander-Katz A, Irvine DJ. Dane EL, et al. Among authors: milling le. Nat Mater. 2022 Jun;21(6):710-720. doi: 10.1038/s41563-022-01251-z. Epub 2022 May 23. Nat Mater. 2022. PMID: 35606429 Free PMC article.
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation.
Bhagchandani SH, Vohidov F, Milling LE, Tong EY, Brown CM, Ramseier ML, Liu B, Fessenden TB, Nguyen HV, Kiel GR, Won L, Langer RS, Spranger S, Shalek AK, Irvine DJ, Johnson JA. Bhagchandani SH, et al. Among authors: milling le. Sci Adv. 2023 Apr 21;9(16):eadg2239. doi: 10.1126/sciadv.adg2239. Epub 2023 Apr 19. Sci Adv. 2023. PMID: 37075115 Free PMC article.
Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity.
Eskiocak U, Guzman W, Wolf B, Cummings C, Milling L, Wu HJ, Ophir M, Lambden C, Bakhru P, Gilmore DC, Ottinger S, Liu L, McConaughy WK, He SQ, Wang C, Leung CL, Lajoie J, Carson WF 4th, Zizlsperger N, Schmidt MM, Anderson AC, Bobrowicz P, Schuetz TJ, Tighe R. Eskiocak U, et al. Among authors: milling l. JCI Insight. 2020 Mar 12;5(5):e133647. doi: 10.1172/jci.insight.133647. JCI Insight. 2020. PMID: 32161196 Free PMC article.
65 results