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Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates.
Monath TP, Soike K, Levenbook I, Zhang ZX, Arroyo J, Delagrave S, Myers G, Barrett AD, Shope RE, Ratterree M, Chambers TJ, Guirakhoo F. Monath TP, et al. Among authors: myers g. Vaccine. 1999 Apr 9;17(15-16):1869-82. doi: 10.1016/s0264-410x(98)00487-3. Vaccine. 1999. PMID: 10217584
A live, attenuated recombinant West Nile virus vaccine.
Monath TP, Liu J, Kanesa-Thasan N, Myers GA, Nichols R, Deary A, McCarthy K, Johnson C, Ermak T, Shin S, Arroyo J, Guirakhoo F, Kennedy JS, Ennis FA, Green S, Bedford P. Monath TP, et al. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6694-9. doi: 10.1073/pnas.0601932103. Epub 2006 Apr 14. Proc Natl Acad Sci U S A. 2006. PMID: 16617103 Free PMC article. Clinical Trial.
A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.
Guirakhoo F, Zhang Z, Myers G, Johnson BW, Pugachev K, Nichols R, Brown N, Levenbook I, Draper K, Cyrek S, Lang J, Fournier C, Barrere B, Delagrave S, Monath TP. Guirakhoo F, et al. Among authors: myers g. J Virol. 2004 Sep;78(18):9998-10008. doi: 10.1128/JVI.78.18.9998-10008.2004. J Virol. 2004. PMID: 15331733 Free PMC article.
During subsequent cell culture passaging of this clone for vaccine production, a single amino acid substitution (K to R) occurred in the envelope (E) protein at residue 204 (E204) (F. Guirakhoo, K. Pugachev, Z. Zhang, G. Myers, I. Levenbook, K. Draper, J. Lang, S. O …
During subsequent cell culture passaging of this clone for vaccine production, a single amino acid substitution (K to R) occurred in the env …
Safety and efficacy of chimeric yellow Fever-dengue virus tetravalent vaccine formulations in nonhuman primates.
Guirakhoo F, Pugachev K, Zhang Z, Myers G, Levenbook I, Draper K, Lang J, Ocran S, Mitchell F, Parsons M, Brown N, Brandler S, Fournier C, Barrere B, Rizvi F, Travassos A, Nichols R, Trent D, Monath T. Guirakhoo F, et al. Among authors: myers g. J Virol. 2004 May;78(9):4761-75. doi: 10.1128/jvi.78.9.4761-4775.2004. J Virol. 2004. PMID: 15078958 Free PMC article.
Clonal vaccinia virus grown in cell culture as a new smallpox vaccine.
Weltzin R, Liu J, Pugachev KV, Myers GA, Coughlin B, Blum PS, Nichols R, Johnson C, Cruz J, Kennedy JS, Ennis FA, Monath TP. Weltzin R, et al. Nat Med. 2003 Sep;9(9):1125-30. doi: 10.1038/nm916. Epub 2003 Aug 17. Nat Med. 2003. PMID: 12925845 Clinical Trial.
Rectal and intranasal immunizations with recombinant urease induce distinct local and serum immune responses in mice and protect against Helicobacter pylori infection.
Kleanthous H, Myers GA, Georgakopoulos KM, Tibbitts TJ, Ingrassia JW, Gray HL, Ding R, Zhang ZZ, Lei W, Nichols R, Lee CK, Ermak TH, Monath TP. Kleanthous H, et al. Among authors: myers ga. Infect Immun. 1998 Jun;66(6):2879-86. doi: 10.1128/IAI.66.6.2879-2886.1998. Infect Immun. 1998. PMID: 9596763 Free PMC article.
1,154 results