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211 results

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Page 1
NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry.
Alessio E, Messori L. Alessio E, et al. Molecules. 2019 May 24;24(10):1995. doi: 10.3390/molecules24101995. Molecules. 2019. PMID: 31137659 Free PMC article. Review.
The encouraging pharmacological performances qualified KP1019 mainly as a cytotoxic agent for the treatment of platinum-resistant colorectal cancers, whereas the non-cytotoxic NAMI-A has gained the reputation of being a very effective antimetastatic drug. A critical …
The encouraging pharmacological performances qualified KP1019 mainly as a cytotoxic agent for the treatment of platinum-resistant colorectal …
The Deceptively Similar Ruthenium(III) Drug Candidates KP1019 and NAMI-A Have Different Actions. What Did We Learn in the Past 30 Years?
Alessio E, Messori L. Alessio E, et al. Met Ions Life Sci. 2018 Feb 5;18:/books/9783110470734/9783110470734-007/9783110470734-011.xml. doi: 10.1515/9783110470734-011. Met Ions Life Sci. 2018. PMID: 29394024 Free article. Review.
The general interest in anticancer metal-based drugs and some encouraging pharmacological results obtained at the beginning of the investigations on innovative Ru-based drugs triggered a lot of attention on NAMI-A and KP1019, the two Ru(III) coordination compounds t …
The general interest in anticancer metal-based drugs and some encouraging pharmacological results obtained at the beginning of the investiga …
Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.
Khanna D, Lin CJF, Furst DE, Goldin J, Kim G, Kuwana M, Allanore Y, Matucci-Cerinic M, Distler O, Shima Y, van Laar JM, Spotswood H, Wagner B, Siegel J, Jahreis A, Denton CP; focuSSced investigators. Khanna D, et al. Lancet Respir Med. 2020 Oct;8(10):963-974. doi: 10.1016/S2213-2600(20)30318-0. Epub 2020 Aug 28. Lancet Respir Med. 2020. PMID: 32866440 Clinical Trial.
Evaluation of NAMI-A Cytotoxic Effects toward Leukemia Cell Lines: A Slippery Ground Giving Misleading Messages.
Bergamo A, Sava G. Bergamo A, et al. Crit Rev Oncog. 2021;26(2):73-78. doi: 10.1615/CritRevOncog.2020036010. Crit Rev Oncog. 2021. PMID: 34347974
Among the many compounds studied, the ruthenium-based complex NAMI-A embodies the unique paradigm of the ability to selectively inhibiting and preventing the development and the growth of distant metastases originating from solid tumors in all the tumor models on wh …
Among the many compounds studied, the ruthenium-based complex NAMI-A embodies the unique paradigm of the ability to selectivel …
The NAMI A - human ferritin system: a biophysical characterization.
Ciambellotti S , Pratesi A , Severi M , Ferraro G , Alessio E , Merlino A , Messori L . Ciambellotti S , et al. Dalton Trans. 2018 Aug 21;47(33):11429-11437. doi: 10.1039/c8dt00860d. Dalton Trans. 2018. PMID: 30063237 Free article.
We observed that the addition of HuHf to NAMI A solutions significantly increases the rate of spontaneous NAMI A hydrolysis suggesting the occurrence of a direct metallodrug-protein interaction. ...We also noted that NAMI A produces a par …
We observed that the addition of HuHf to NAMI A solutions significantly increases the rate of spontaneous NAMI A …
NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug.
Yuan S , Chen S , Wu H , Jiang H , Zheng S , Zhang Q , Liu Y . Yuan S , et al. Chem Commun (Camb). 2020 Jan 30;56(9):1397-1400. doi: 10.1039/c9cc08775c. Chem Commun (Camb). 2020. PMID: 31912815
NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure and disruption of the DNA recognition of Sp1. Interestingly, Sp1 is more susceptible than other zinc finger proteins to NAMI-A, …
NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure a …
Comparison of KP1019 and NAMI-A in tumour-mimetic environments.
Gransbury GK, Kappen P, Glover CJ, Hughes JN, Levina A, Lay PA, Musgrave IF, Harris HH. Gransbury GK, et al. Metallomics. 2016 Aug 1;8(8):762-73. doi: 10.1039/c6mt00145a. Metallomics. 2016. PMID: 27460862
The potential reduction of NAMI-A and KP1019 in the hypoxic environment of a tumour model of neuroblastoma was examined. ...Laser-ablation inductively-coupled plasma mass spectrometry showed KP1019 and NAMI-A penetration into the spheroid hypoxic regio …
The potential reduction of NAMI-A and KP1019 in the hypoxic environment of a tumour model of neuroblastoma was examined. ...La …
α-Synuclein as a Target for Metallo-Anti-Neurodegenerative Agents.
Cao K, Zhu Y, Hou Z, Liu M, Yang Y, Hu H, Dai Y, Wang Y, Yuan S, Huang G, Mei J, Sadler PJ, Liu Y. Cao K, et al. Angew Chem Int Ed Engl. 2023 Jan 2;62(1):e202215360. doi: 10.1002/anie.202215360. Epub 2022 Nov 30. Angew Chem Int Ed Engl. 2023. PMID: 36345707
NAMI-A abolishes the cytotoxicity of alpha-syn towards neuronal cells and mitigates neurodegeneration and motor impairments in a rat model of Parkinson's. Multinuclear NMR and MS analyses show that NAMI-A binds to residues involved in protein aggregati …
NAMI-A abolishes the cytotoxicity of alpha-syn towards neuronal cells and mitigates neurodegeneration and motor impairments in …
A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis.
Rovin BH, Solomons N, Pendergraft WF 3rd, Dooley MA, Tumlin J, Romero-Diaz J, Lysenko L, Navarra SV, Huizinga RB; AURA-LV Study Group. Rovin BH, et al. Kidney Int. 2019 Jan;95(1):219-231. doi: 10.1016/j.kint.2018.08.025. Epub 2018 Nov 9. Kidney Int. 2019. PMID: 30420324 Free article. Clinical Trial.
The rational design of NAMI-A-loaded mesoporous silica nanoparticles as antiangiogenic nanosystems.
Hu H , You Y , He L , Chen T . Hu H , et al. J Mater Chem B. 2015 Aug 14;3(30):6338-6346. doi: 10.1039/c5tb00612k. Epub 2015 Jul 9. J Mater Chem B. 2015. PMID: 32262752
The results revealed that NAMI-A@MSN-RGD remarkably enhanced the cellular uptake and antiangiogenic efficacy in contrast to bare NAMI-A in vitro. The nanosystem of NAMI-A@MSN-RGD also exhibited inspiring antiangiogenic action in vivo. ...
The results revealed that NAMI-A@MSN-RGD remarkably enhanced the cellular uptake and antiangiogenic efficacy in contrast to ba …
211 results