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The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.
Schulte T, Mikaelsson C, Beaussart A, Kikhney A, Deshmukh M, Wolniak S, Pathak A, Ebel C, Löfling J, Fogolari F, Henriques-Normark B, Dufrêne YF, Svergun D, Nygren PÅ, Achour A. Schulte T, et al. Among authors: nygren pa. Sci Rep. 2016 Sep 1;6:32371. doi: 10.1038/srep32371. Sci Rep. 2016. PMID: 27582320 Free PMC article.
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.
Subramanian K, Neill DR, Malak HA, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren PÅ, Plant L, Kadioglu A, Henriques-Normark B. Subramanian K, et al. Among authors: nygren pa. Nat Microbiol. 2019 Jan;4(1):62-70. doi: 10.1038/s41564-018-0280-x. Epub 2018 Nov 12. Nat Microbiol. 2019. PMID: 30420782 Free PMC article.
Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Hafstrand I, Sayitoglu EC, Apavaloaei A, Josey BJ, Sun R, Han X, Pellegrino S, Ozkazanc D, Potens R, Janssen L, Nilvebrant J, Nygren PÅ, Sandalova T, Springer S, Georgoudaki AM, Duru AD, Achour A. Hafstrand I, et al. Among authors: nygren pa. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5055-5060. doi: 10.1073/pnas.1807656116. Epub 2019 Feb 26. Proc Natl Acad Sci U S A. 2019. PMID: 30808808 Free PMC article.
Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination.
Duru AD, Sun R, Allerbring EB, Chadderton J, Kadri N, Han X, Peqini K, Uchtenhagen H, Madhurantakam C, Pellegrino S, Sandalova T, Nygren PÅ, Turner SJ, Achour A. Duru AD, et al. Among authors: nygren pa. PLoS Pathog. 2020 May 4;16(5):e1008244. doi: 10.1371/journal.ppat.1008244. eCollection 2020 May. PLoS Pathog. 2020. PMID: 32365082 Free PMC article.
123 results