O'Connor W - Search Results

1

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.

Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Eisenbarth SC, et al. Nature. 2008 Jun 19;453(7198):1122-6. doi: 10.1038/nature06939. Epub 2008 May 21. Nature. 2008. PMID: 18496530 Free PMC article.

2

A protective function for interleukin 17A in T cell-mediated intestinal inflammation.

O'Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA. O'Connor W Jr, et al. Nat Immunol. 2009 Jun;10(6):603-9. doi: 10.1038/ni.1736. Nat Immunol. 2009. PMID: 19448631 Free PMC article.

3

The dual nature of T(H)17 cells: shifting the focus to function.

O'Connor W Jr, Zenewicz LA, Flavell RA. O'Connor W Jr, et al. Nat Immunol. 2010 Jun;11(6):471-6. doi: 10.1038/ni.1882. Epub 2010 May 18. Nat Immunol. 2010. PMID: 20485275

4

Control of TH17 cells occurs in the small intestine.

Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Esplugues E, et al. Nature. 2011 Jul 17;475(7357):514-8. doi: 10.1038/nature10228. Nature. 2011. PMID: 21765430 Free PMC article.

5

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. Huber S, et al. Nature. 2012 Nov 8;491(7423):259-63. doi: 10.1038/nature11535. Epub 2012 Oct 17. Nature. 2012. PMID: 23075849 Free PMC article.

6

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP. Willingham SB, et al. Cell Host Microbe. 2007 Sep 13;2(3):147-59. doi: 10.1016/j.chom.2007.07.009. Cell Host Microbe. 2007. PMID: 18005730 Free PMC article.

7

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.

Huber S, Gagliani N, Esplugues E, O'Connor W Jr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. Huber S, et al. Immunity. 2011 Apr 22;34(4):554-65. doi: 10.1016/j.immuni.2011.01.020. Immunity. 2011. PMID: 21511184 Free PMC article.

8

Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.

Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W Jr, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA. Kamanaka M, et al. J Exp Med. 2011 May 9;208(5):1027-40. doi: 10.1084/jem.20102149. Epub 2011 Apr 25. J Exp Med. 2011. PMID: 21518800 Free PMC article.

9

Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.

O'Connor W Jr, Harton JA, Zhu X, Linhoff MW, Ting JP. O'Connor W Jr, et al. J Immunol. 2003 Dec 15;171(12):6329-33. doi: 10.4049/jimmunol.171.12.6329. J Immunol. 2003. PMID: 14662828

10

CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function.

Conti BJ, Davis BK, Zhang J, O'connor W Jr, Williams KL, Ting JP. Conti BJ, et al. J Biol Chem. 2005 May 6;280(18):18375-85. doi: 10.1074/jbc.M413169200. Epub 2005 Feb 10. J Biol Chem. 2005. PMID: 15705585 Free article.

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