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Does difference between label and actual potency of factor VIII concentrate affect pharmacokinetic-guided dosing of replacement therapy in haemophilia A?
Goedhart TMHJ, Bukkems LH, van Moort I, Spence CC, Zwaan MC, de Maat MPM, Mathôt RAA, Cnossen MH; OPTI-CLOT study group and SYMPHONY consortium. Goedhart TMHJ, et al. Haemophilia. 2022 Jul;28(4):610-618. doi: 10.1111/hae.14575. Epub 2022 May 8. Haemophilia. 2022. PMID: 35526235 Free PMC article. Clinical Trial.
A new population pharmacokinetic model for recombinant factor IX-Fc fusion concentrate including young children with haemophilia B.
Koopman SF, Goedhart TMHJ, Bukkems LH, Mulders TM, Leebeek FWG, Fijnvandraat K, Coppens M, Mathias M, Collins PW, Tait RC, Bagot CN, Curry N, Payne J, Chowdary P, Cnossen MH, Mathôt RAA; OPTI-CLOT study group and SYMPHONY consortium. Koopman SF, et al. Br J Clin Pharmacol. 2024 Jan;90(1):220-231. doi: 10.1111/bcp.15881. Epub 2023 Sep 12. Br J Clin Pharmacol. 2024. PMID: 37567779