Offringa R - Search Results

1

CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity.

Bijker MS, van den Eeden SJ, Franken KL, Melief CJ, Offringa R, van der Burg SH. Bijker MS, et al. Among authors: offringa r. J Immunol. 2007 Oct 15;179(8):5033-40. doi: 10.4049/jimmunol.179.8.5033. J Immunol. 2007. PMID: 17911588

2

In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway.

Diehl L, van Mierlo GJ, den Boer AT, van der Voort E, Fransen M, van Bostelen L, Krimpenfort P, Melief CJ, Mittler R, Toes RE, Offringa R. Diehl L, et al. Among authors: offringa r. J Immunol. 2002 Apr 15;168(8):3755-62. doi: 10.4049/jimmunol.168.8.3755. J Immunol. 2002. PMID: 11937526

3

Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides.

Zwaveling S, Ferreira Mota SC, Nouta J, Johnson M, Lipford GB, Offringa R, van der Burg SH, Melief CJ. Zwaveling S, et al. Among authors: offringa r. J Immunol. 2002 Jul 1;169(1):350-8. doi: 10.4049/jimmunol.169.1.350. J Immunol. 2002. PMID: 12077264

4

Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides.

Kessler JH, Mommaas B, Mutis T, Huijbers I, Vissers D, Benckhuijsen WE, Schreuder GM, Offringa R, Goulmy E, Melief CJ, van der Burg SH, Drijfhout JW. Kessler JH, et al. Among authors: offringa r. Hum Immunol. 2003 Feb;64(2):245-55. doi: 10.1016/s0198-8859(02)00787-5. Hum Immunol. 2003. PMID: 12559627

5

Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction.

Boonman ZF, van Mierlo GJ, Fransen MF, Franken KL, Offringa R, Melief CJ, Jager MJ, Toes RE. Boonman ZF, et al. Among authors: offringa r. J Immunol. 2004 Feb 1;172(3):1567-74. doi: 10.4049/jimmunol.172.3.1567. J Immunol. 2004. PMID: 14734736

6

The tumoricidal activity of memory CD8+ T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment.

den Boer AT, van Mierlo GJ, Fransen MF, Melief CJ, Offringa R, Toes RE. den Boer AT, et al. Among authors: offringa r. J Immunol. 2004 May 15;172(10):6074-9. doi: 10.4049/jimmunol.172.10.6074. J Immunol. 2004. PMID: 15128791

7

Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model.

Welters MJ, Filippov DV, van den Eeden SJ, Franken KL, Nouta J, Valentijn AR, van der Marel GA, Overkleeft HS, Lipford G, Offringa R, Melief CJ, van Boom JH, van der Burg SH, Drijfhout JW. Welters MJ, et al. Among authors: offringa r. Vaccine. 2004 Dec 2;23(3):305-11. doi: 10.1016/j.vaccine.2004.06.008. Vaccine. 2004. PMID: 15530672

8

Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication.

van Mierlo GJ, Boonman ZF, Dumortier HM, den Boer AT, Fransen MF, Nouta J, van der Voort EI, Offringa R, Toes RE, Melief CJ. van Mierlo GJ, et al. Among authors: offringa r. J Immunol. 2004 Dec 1;173(11):6753-9. doi: 10.4049/jimmunol.173.11.6753. J Immunol. 2004. PMID: 15557168

9

Antigen presentation by an immature myeloid dendritic cell line does not cause CTL deletion in vivo, but generates CD8+ central memory-like T cells that can be rescued for full effector function.

Dumortier H, van Mierlo GJ, Egan D, van Ewijk W, Toes RE, Offringa R, Melief CJ. Dumortier H, et al. Among authors: offringa r. J Immunol. 2005 Jul 15;175(2):855-63. doi: 10.4049/jimmunol.175.2.855. J Immunol. 2005. PMID: 16002683

10

Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists.

Welters MJ, Bijker MS, van den Eeden SJ, Franken KL, Melief CJ, Offringa R, van der Burg SH. Welters MJ, et al. Among authors: offringa r. Vaccine. 2007 Feb 9;25(8):1379-89. doi: 10.1016/j.vaccine.2006.10.049. Epub 2006 Nov 7. Vaccine. 2007. PMID: 17123670

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