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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J. Poeck H, et al. Among authors: peschel c. Nat Immunol. 2010 Jan;11(1):63-9. doi: 10.1038/ni.1824. Epub 2009 Nov 15. Nat Immunol. 2010. PMID: 19915568
Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.
Gross O, Grupp C, Steinberg C, Zimmermann S, Strasser D, Hannesschläger N, Reindl W, Jonsson H, Huo H, Littman DR, Peschel C, Yokoyama WM, Krug A, Ruland J. Gross O, et al. Among authors: peschel c. Blood. 2008 Sep 15;112(6):2421-8. doi: 10.1182/blood-2007-11-123513. Epub 2008 Jan 11. Blood. 2008. PMID: 18192506 Free PMC article.
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.
Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C, Ruland J. Pechloff K, et al. Among authors: peschel c. J Exp Med. 2010 May 10;207(5):1031-44. doi: 10.1084/jem.20092042. Epub 2010 May 3. J Exp Med. 2010. PMID: 20439541 Free PMC article.
Card9 controls Dectin-1-induced T-cell cytotoxicity and tumor growth in mice.
Haas T, Heidegger S, Wintges A, Bscheider M, Bek S, Fischer JC, Eisenkolb G, Schmickl M, Spoerl S, Peschel C, Poeck H, Ruland J. Haas T, et al. Among authors: peschel c. Eur J Immunol. 2017 May;47(5):872-879. doi: 10.1002/eji.201646775. Epub 2017 Apr 10. Eur J Immunol. 2017. PMID: 28295265 Free PMC article.
398 results