Pitt G - Search Results

1

Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ. Sanders SJ, et al. Among authors: pitt g. Trends Neurosci. 2018 Jul;41(7):442-456. doi: 10.1016/j.tins.2018.03.011. Epub 2018 Apr 23. Trends Neurosci. 2018. PMID: 29691040 Free PMC article. Review.

2

Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.

Wang HG, Bavley CC, Li A, Jones RM, Hackett J, Bayleyen Y, Lee FS, Rajadhyaksha AM, Pitt GS. Wang HG, et al. JCI Insight. 2021 Aug 9;6(15):e150698. doi: 10.1172/jci.insight.150698. JCI Insight. 2021. PMID: 34156984 Free PMC article.

3

Solution structure of the NaV1.2 C-terminal EF-hand domain.

Miloushev VZ, Levine JA, Arbing MA, Hunt JF, Pitt GS, Palmer AG 3rd. Miloushev VZ, et al. Among authors: pitt gs. J Biol Chem. 2009 Mar 6;284(10):6446-54. doi: 10.1074/jbc.M807401200. Epub 2009 Jan 7. J Biol Chem. 2009. PMID: 19129176 Free PMC article.

4

Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Chen-Izu Y, et al. J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. J Physiol. 2015. PMID: 25772290 Free PMC article. Review.

5

Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.

Abrams J, Roybal D, Chakouri N, Katchman AN, Weinberg R, Yang L, Chen BX, Zakharov SI, Hennessey JA, Avula UMR, Diaz J, Wang C, Wan EY, Pitt GS, Ben-Johny M, Marx SO. Abrams J, et al. JCI Insight. 2020 Oct 2;5(19):e141736. doi: 10.1172/jci.insight.141736. JCI Insight. 2020. PMID: 32870823 Free PMC article.

6

An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.

Gade AR, Marx SO, Pitt GS. Gade AR, et al. J Gen Physiol. 2020 Feb 3;152(2):e201912434. doi: 10.1085/jgp.201912434. J Gen Physiol. 2020. PMID: 31865383 Free PMC article.

7

Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.

Pitt GS, Lee SY. Pitt GS, et al. Protein Sci. 2016 Sep;25(9):1573-84. doi: 10.1002/pro.2960. Epub 2016 Jun 13. Protein Sci. 2016. PMID: 27262167 Free PMC article. Review.

8

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na_v1.5.

Wang Z, Vermij SH, Sottas V, Shestak A, Ross-Kaschitza D, Zaklyazminskaya EV, Hudmon A, Pitt GS, Rougier JS, Abriel H. Wang Z, et al. Channels (Austin). 2020 Dec;14(1):268-286. doi: 10.1080/19336950.2020.1805999. Channels (Austin). 2020. PMID: 32815768 Free PMC article.

9

A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.

Wang HG, Zhu W, Kanter RJ, Silva JR, Honeywell C, Gow RM, Pitt GS. Wang HG, et al. J Mol Cell Cardiol. 2016 Mar;92:52-62. doi: 10.1016/j.yjmcc.2016.01.014. Epub 2016 Jan 19. J Mol Cell Cardiol. 2016. PMID: 26801742 Free PMC article.

10

Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.

Wang C, Chung BC, Yan H, Wang HG, Lee SY, Pitt GS. Wang C, et al. Nat Commun. 2014 Sep 18;5:4896. doi: 10.1038/ncomms5896. Nat Commun. 2014. PMID: 25232683 Free PMC article.

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