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A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature. 2020 Jun;582(7812):443-447. doi: 10.1038/s41586-020-2250-8. Epub 2020 Apr 29.
Nature. 2020.
PMID: 32499642
5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis.
Ramírez D, Mejia-Gutierrez M, Insuasty B, Rinné S, Kiper AK, Platzk M, Müller T, Decher N, Quiroga J, De-la-Torre P, González W.
Ramírez D, et al. Among authors: platzk m.
Molecules. 2021 Jun 25;26(13):3897. doi: 10.3390/molecules26133897.
Molecules. 2021.
PMID: 34202296
Free PMC article.
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Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung.
Villaseñor-Altamirano AB, Jain D, Jeong Y, Menon JA, Kamiya M, Haider H, Manandhar R, Sheikh MDA, Athar H, Merriam LT, Ryu MH, Sasaki T, Castaldi PJ, Rao DA, Sholl LM, Vivero M, Hersh CP, Zhou X, Veerkamp J, Yun JH, Kim EY; MassGeneralBrigham - Bayer Pulmonary Drug Discovery Laboratory.
Villaseñor-Altamirano AB, et al.
Am J Respir Crit Care Med. 2023 Dec 1;208(11):1177-1195. doi: 10.1164/rccm.202305-0924OC.
Am J Respir Crit Care Med. 2023.
PMID: 37756440
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