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IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.
Friedrich M, Pohin M, Jackson MA, Korsunsky I, Bullers SJ, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Thomas T, Ravindran R, Tandon R, Peres RS, Sharpe H, Wei K, Watts GFM, Mann EH, Geremia A, Attar M; Oxford IBD Cohort Investigators; Roche Fibroblast Network Consortium; McCuaig S, Thomas L, Collantes E, Uhlig HH, Sansom SN, Easton A, Raychaudhuri S, Travis SP, Powrie FM. Friedrich M, et al. Among authors: powrie fm. Nat Med. 2021 Nov;27(11):1970-1981. doi: 10.1038/s41591-021-01520-5. Epub 2021 Oct 21. Nat Med. 2021. PMID: 34675383 Free PMC article.
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses.
Heuberger CE, Janney A, Ilott N, Bertocchi A, Pott S, Gu Y, Pohin M, Friedrich M, Mann EH, Pearson C, Powrie FM, Pott J, Thornton E, Maloy KJ. Heuberger CE, et al. Among authors: powrie fm. Mucosal Immunol. 2023 May 18:S1933-0219(23)00032-6. doi: 10.1016/j.mucimm.2023.05.001. Online ahead of print. Mucosal Immunol. 2023. PMID: 37209960 Free article.
Regulatory T cells and immune tolerance in the intestine.
Harrison OJ, Powrie FM. Harrison OJ, et al. Among authors: powrie fm. Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7):a018341. doi: 10.1101/cshperspect.a018341. Cold Spring Harb Perspect Biol. 2013. PMID: 23818502 Free PMC article. Review.