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Hepatocyte growth factor sensitizes brain tumors to c-MET kinase inhibition.
Zhang Y, Farenholtz KE, Yang Y, Guessous F, Dipierro CG, Calvert VS, Deng J, Schiff D, Xin W, Lee JK, Purow B, Christensen J, Petricoin E, Abounader R. Zhang Y, et al. Among authors: purow b. Clin Cancer Res. 2013 Mar 15;19(6):1433-44. doi: 10.1158/1078-0432.CCR-12-2832. Epub 2013 Feb 5. Clin Cancer Res. 2013. PMID: 23386689 Free PMC article.
Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms.
Olmez I, Brenneman B, Xiao A, Serbulea V, Benamar M, Zhang Y, Manigat L, Abbas T, Lee J, Nakano I, Godlewski J, Bronisz A, Abounader R, Leitinger N, Purow B. Olmez I, et al. Among authors: purow b. Clin Cancer Res. 2017 Nov 15;23(22):6958-6968. doi: 10.1158/1078-0432.CCR-17-0803. Epub 2017 Aug 16. Clin Cancer Res. 2017. PMID: 28814434 Free PMC article.
CDK4/6 inhibition is more active against the glioblastoma proneural subtype.
Li M, Xiao A, Floyd D, Olmez I, Lee J, Godlewski J, Bronisz A, Bhat KPL, Sulman EP, Nakano I, Purow B. Li M, et al. Among authors: purow b. Oncotarget. 2017 Jul 21;8(33):55319-55331. doi: 10.18632/oncotarget.19429. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903422 Free PMC article.
Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha.
Olmez I, Love S, Xiao A, Manigat L, Randolph P, McKenna BD, Neal BP, Boroda S, Li M, Brenneman B, Abounader R, Floyd D, Lee J, Nakano I, Godlewski J, Bronisz A, Sulman EP, Mayo M, Gioeli D, Weber M, Harris TE, Purow B. Olmez I, et al. Among authors: purow b. Neuro Oncol. 2018 Jan 22;20(2):192-202. doi: 10.1093/neuonc/nox119. Neuro Oncol. 2018. PMID: 29048560 Free PMC article.
FHL2 interacts with EGFR to promote glioblastoma growth.
Sun L, Yu S, Xu H, Zheng Y, Lin J, Wu M, Wang J, Wang A, Lan Q, Furnari F, Cavenee W, Purow B, Li M. Sun L, et al. Among authors: purow b. Oncogene. 2018 Mar;37(10):1386-1398. doi: 10.1038/s41388-017-0068-0. Epub 2018 Jan 11. Oncogene. 2018. PMID: 29321665 Free PMC article.
Statins affect human glioblastoma and other cancers through TGF-β inhibition.
Xiao A, Brenneman B, Floyd D, Comeau L, Spurio K, Olmez I, Lee J, Nakano I, Godlewski J, Bronisz A, Kagaya N, Shin-Ya K, Purow B. Xiao A, et al. Among authors: purow b. Oncotarget. 2019 Mar 1;10(18):1716-1728. doi: 10.18632/oncotarget.26733. eCollection 2019 Mar 1. Oncotarget. 2019. PMID: 30899443 Free PMC article.
88 results