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The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex.
Verweij MC, Koppers-Lalic D, Loch S, Klauschies F, de la Salle H, Quinten E, Lehner PJ, Mulder A, Knittler MR, Tampé R, Koch J, Ressing ME, Wiertz EJ. Verweij MC, et al. Among authors: quinten e. J Immunol. 2008 Oct 1;181(7):4894-907. doi: 10.4049/jimmunol.181.7.4894. J Immunol. 2008. PMID: 18802093
Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.
Koppers-Lalic D, Verweij MC, Lipińska AD, Wang Y, Quinten E, Reits EA, Koch J, Loch S, Marcondes Rezende M, Daus F, Bieńkowska-Szewczyk K, Osterrieder N, Mettenleiter TC, Heemskerk MH, Tampé R, Neefjes JJ, Chowdhury SI, Ressing ME, Rijsewijk FA, Wiertz EJ. Koppers-Lalic D, et al. Among authors: quinten e. PLoS Pathog. 2008 May 30;4(5):e1000080. doi: 10.1371/journal.ppat.1000080. PLoS Pathog. 2008. PMID: 18516302 Free PMC article.
Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.
Unger WW, Velthuis J, Abreu JR, Laban S, Quinten E, Kester MG, Reker-Hadrup S, Bakker AH, Duinkerken G, Mulder A, Franken KL, Hilbrands R, Keymeulen B, Peakman M, Ossendorp F, Drijfhout JW, Schumacher TN, Roep BO. Unger WW, et al. Among authors: quinten e. J Autoimmun. 2011 Nov;37(3):151-9. doi: 10.1016/j.jaut.2011.05.012. Epub 2011 Jun 1. J Autoimmun. 2011. PMID: 21636247
Constitutive and IFNgamma-induced activation of MHC2TA promoter type III in human melanoma cell lines is governed by separate regulatory elements within the PIII upstream regulatory region.
van der Stoep N, Quinten E, Alblas G, Plancke A, van Eggermond MC, Holling TM, van den Elsen PJ. van der Stoep N, et al. Among authors: quinten e. Mol Immunol. 2007 Mar;44(8):2036-46. doi: 10.1016/j.molimm.2006.09.013. Epub 2006 Oct 25. Mol Immunol. 2007. PMID: 17067677
Transcriptional regulation of the MHC class II trans-activator (CIITA) promoter III: identification of a novel regulatory region in the 5'-untranslated region and an important role for cAMP-responsive element binding protein 1 and activating transcription factor-1 in CIITA-promoter III transcriptional activation in B lymphocytes.
van der Stoep N, Quinten E, van den Elsen PJ. van der Stoep N, et al. Among authors: quinten e. J Immunol. 2002 Nov 1;169(9):5061-71. doi: 10.4049/jimmunol.169.9.5061. J Immunol. 2002. PMID: 12391222
Longitudinal immune responses and gene expression profiles in type 1 leprosy reactions.
Geluk A, van Meijgaarden KE, Wilson L, Bobosha K, van der Ploeg-van Schip JJ, van den Eeden SJ, Quinten E, Dijkman K, Franken KL, Haisma EM, Haks MC, van Hees CL, Ottenhoff TH. Geluk A, et al. Among authors: quinten e. J Clin Immunol. 2014 Feb;34(2):245-55. doi: 10.1007/s10875-013-9979-x. Epub 2013 Dec 27. J Clin Immunol. 2014. PMID: 24370984
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