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Page 1
IFITM proteins assist cellular uptake of diverse linked chemotypes.
Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM. Lou K, et al. Science. 2022 Dec 9;378(6624):1097-1104. doi: 10.1126/science.abl5829. Epub 2022 Dec 8. Science. 2022. PMID: 36480603 Free PMC article.
N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.
Kuzuoglu-Ozturk D, Aksoy O, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Wong-Michalak S, Shao H, Wechsler-Reya R, Phillips JJ, Gestwicki JE, Ruggero D, Weiss WA. Kuzuoglu-Ozturk D, et al. Cancer Res. 2023 Jan 4;83(1):130-140. doi: 10.1158/0008-5472.CAN-22-0945. Cancer Res. 2023. PMID: 36264168 Free PMC article.
Brain-restricted mTOR inhibition with binary pharmacology.
Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM. Zhang Z, et al. Nature. 2022 Sep;609(7928):822-828. doi: 10.1038/s41586-022-05213-y. Epub 2022 Sep 14. Nature. 2022. PMID: 36104566 Free PMC article.
Tissue-restricted inhibition of mTOR using chemical genetics.
Wassarman DR, Bankapalli K, Pallanck LJ, Shokat KM. Wassarman DR, et al. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2204083119. doi: 10.1073/pnas.2204083119. Epub 2022 Sep 12. Proc Natl Acad Sci U S A. 2022. PMID: 36095197 Free PMC article.
EGFR ligands dictate tumour suppression.
Beytagh MC, Weiss WA. Beytagh MC, et al. Nat Cell Biol. 2022 Aug;24(8):1189-1191. doi: 10.1038/s41556-022-00967-z. Nat Cell Biol. 2022. PMID: 35915160 Free PMC article.
27 results