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Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes.
Remans PH, Gringhuis SI, van Laar JM, Sanders ME, Papendrecht-van der Voort EA, Zwartkruis FJ, Levarht EW, Rosas M, Coffer PJ, Breedveld FC, Bos JL, Tak PP, Verweij CL, Reedquist KA. Remans PH, et al. Among authors: reedquist ka. J Immunol. 2004 Jul 15;173(2):920-31. doi: 10.4049/jimmunol.173.2.920. J Immunol. 2004. PMID: 15240679
The presumed hyporesponsive behavior of rheumatoid arthritis T lymphocytes can be attributed to spontaneous ex vivo apoptosis rather than defects in T cell receptor signaling.
Abreu JR, Grabiec AM, Krausz S, Spijker R, Burakowski T, Maslinski W, Eldering E, Tak PP, Reedquist KA. Abreu JR, et al. Among authors: reedquist ka. J Immunol. 2009 Jul 1;183(1):621-30. doi: 10.4049/jimmunol.0803278. Epub 2009 Jun 12. J Immunol. 2009. PMID: 19525395 Free article.
Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
Hoek RM, de Launay D, Kop EN, Yilmaz-Elis AS, Lin F, Reedquist KA, Verbeek JS, Medof ME, Tak PP, Hamann J. Hoek RM, et al. Among authors: reedquist ka. Arthritis Rheum. 2010 Apr;62(4):1036-42. doi: 10.1002/art.27347. Arthritis Rheum. 2010. PMID: 20131275 Free article.
Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.
de Launay D, Vreijling J, Hartkamp LM, Karpus ON, Abreu JR, van Maanen MA, Sanders ME, Grabiec AM, Hamann J, Ørum H, Vervoordeldonk MJ, Fluiter K, Tak PP, Reedquist KA. de Launay D, et al. Among authors: reedquist ka. Am J Pathol. 2010 Dec;177(6):3010-24. doi: 10.2353/ajpath.2010.091053. Epub 2010 Oct 22. Am J Pathol. 2010. PMID: 20971740 Free PMC article.
85 results